Asthma treatment in pregnancy

A randomized controlled study

P. J. Wendel, S. M. Ramin, C. Barnett-Hamm, T. F. Rowe, F. G. Cunningham

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

OBJECTIVE: Our purpose was to study the effect of inhaled corticosteroids on asthma exacerbations in pregnancy. STUDY DESIGN: We prospectively studied 84 pregnant women with 105 asthma exacerbations. Women were hospitalized if the forced expiratory volume in 1 second was <70% after sequential bronchodilator therapy. They were randomly assigned to receive either intravenous aminophylline and inhaled β2-adrenergic receptor agonist or intravenous methylprednisolone and a β2-adrenergic receptor agonist. At discharge women were randomly assigned to receive either inhaled beclomethasone, β2-adrenergic receptor agonist, and an oral corticosteroid taper or a β2-adrenergic receptor agonist and a corticosteroid taper. RESULTS: Sixty-five (62%) of 105 women with exacerbation required hospitalization. Aminophylline did not shorten response time or decrease hospital stay. Readmission rate was decreased by 55% in women given inhaled beclomethasone (33% vs 12%, p < 0.05, odds ratio 3.63, 95% confidence interval 1.01 to 13.08). Pregnancy-induced hypertension and cesarean delivery were increased over those of the general population. CONCLUSIONS: Intravenous aminophylline offers no therapeutic advantages. Continuous inhaled corticosteroids reduced the need for subsequent admissions.

Original languageEnglish (US)
Pages (from-to)150-154
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume175
Issue number1
StatePublished - 1996

Fingerprint

Adrenergic Agonists
Aminophylline
Adrenal Cortex Hormones
Asthma
Beclomethasone
Pregnancy
Pregnancy Induced Hypertension
Bronchodilator Agents
Methylprednisolone
Forced Expiratory Volume
Therapeutics
Reaction Time
Pregnant Women
Length of Stay
Hospitalization
Odds Ratio
Confidence Intervals
Population

Keywords

  • aminophylline
  • Asthma
  • inhaled corticosteroids

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Wendel, P. J., Ramin, S. M., Barnett-Hamm, C., Rowe, T. F., & Cunningham, F. G. (1996). Asthma treatment in pregnancy: A randomized controlled study. American Journal of Obstetrics and Gynecology, 175(1), 150-154.

Asthma treatment in pregnancy : A randomized controlled study. / Wendel, P. J.; Ramin, S. M.; Barnett-Hamm, C.; Rowe, T. F.; Cunningham, F. G.

In: American Journal of Obstetrics and Gynecology, Vol. 175, No. 1, 1996, p. 150-154.

Research output: Contribution to journalArticle

Wendel, PJ, Ramin, SM, Barnett-Hamm, C, Rowe, TF & Cunningham, FG 1996, 'Asthma treatment in pregnancy: A randomized controlled study', American Journal of Obstetrics and Gynecology, vol. 175, no. 1, pp. 150-154.
Wendel, P. J. ; Ramin, S. M. ; Barnett-Hamm, C. ; Rowe, T. F. ; Cunningham, F. G. / Asthma treatment in pregnancy : A randomized controlled study. In: American Journal of Obstetrics and Gynecology. 1996 ; Vol. 175, No. 1. pp. 150-154.
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