Asymmetric pattern of cerebrovascular lesions in patients after left ventricular assist device implantation

Tomoko S. Kato; Takeyoshi Ota; P. Christian Schulze; Maryjane Farr; Ulrich Jorde; Hiroo Takayama; Yoshifumi Naka; Toru Yamashita; Donna M. Mancini

doi:10.1161/STROKEAHA.111.639682

Asymmetric pattern of cerebrovascular lesions in patients after left ventricular assist device implantation

Tomoko S. Kato, Takeyoshi Ota, P. Christian Schulze, Maryjane Farr, Ulrich Jorde, Hiroo Takayama, Yoshifumi Naka, Toru Yamashita, Donna M. Mancini

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

BACKGROUND AND PURPOSE-: Stroke is a major adverse event after left ventricular assist device (LVAD) surgery. The purpose of this study was to describe differences in hemispheric distribution of stroke in LVAD patients. METHODS-: We reviewed 317 consecutive patients who underwent LVAD surgery between November 2000 and July 2011. Stroke during LVAD support was analyzed. RESULTS-: In total, 46 strokes occurred at 76.0±96.8 days postoperatively. Among the 46 strokes, 27 events (58.7%) occurred in right hemisphere, 13 events (28.2%) in the left hemisphere, 3 events (8.7%) occurred bilaterally, and 2 events (4.3%) were vertebrobasilar lesions. The right hemispheric stroke was significantly more common in patients with postoperative infection compared with left hemispheric events. CONCLUSIONS-: Stroke after LVAD implantation has a right hemispheric predominance. This finding suggests LVAD-related thrombus in the setting of infection and/or the anatomic configuration of LVAD outflow cannula-ascending aorta anastomosis to be highly associated with stroke after LVAD surgery.

Original language	English (US)
Pages (from-to)	872-874
Number of pages	3
Journal	Stroke
Volume	43
Issue number	3
DOIs	https://doi.org/10.1161/STROKEAHA.111.639682
State	Published - Mar 2012
Externally published	Yes

Keywords

acute stroke
cardiac surgery
infectious disease

ASJC Scopus subject areas

Clinical Neurology
Cardiology and Cardiovascular Medicine
Advanced and Specialized Nursing

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10.1161/STROKEAHA.111.639682

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title = "Asymmetric pattern of cerebrovascular lesions in patients after left ventricular assist device implantation",

abstract = "BACKGROUND AND PURPOSE-: Stroke is a major adverse event after left ventricular assist device (LVAD) surgery. The purpose of this study was to describe differences in hemispheric distribution of stroke in LVAD patients. METHODS-: We reviewed 317 consecutive patients who underwent LVAD surgery between November 2000 and July 2011. Stroke during LVAD support was analyzed. RESULTS-: In total, 46 strokes occurred at 76.0±96.8 days postoperatively. Among the 46 strokes, 27 events (58.7%) occurred in right hemisphere, 13 events (28.2%) in the left hemisphere, 3 events (8.7%) occurred bilaterally, and 2 events (4.3%) were vertebrobasilar lesions. The right hemispheric stroke was significantly more common in patients with postoperative infection compared with left hemispheric events. CONCLUSIONS-: Stroke after LVAD implantation has a right hemispheric predominance. This finding suggests LVAD-related thrombus in the setting of infection and/or the anatomic configuration of LVAD outflow cannula-ascending aorta anastomosis to be highly associated with stroke after LVAD surgery.",

keywords = "acute stroke, cardiac surgery, infectious disease",

author = "Kato, {Tomoko S.} and Takeyoshi Ota and Schulze, {P. Christian} and Maryjane Farr and Ulrich Jorde and Hiroo Takayama and Yoshifumi Naka and Toru Yamashita and Mancini, {Donna M.}",

year = "2012",

month = mar,

doi = "10.1161/STROKEAHA.111.639682",

language = "English (US)",

volume = "43",

pages = "872--874",

journal = "Stroke",

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T1 - Asymmetric pattern of cerebrovascular lesions in patients after left ventricular assist device implantation

AU - Kato, Tomoko S.

AU - Ota, Takeyoshi

AU - Schulze, P. Christian

AU - Farr, Maryjane

AU - Jorde, Ulrich

AU - Takayama, Hiroo

AU - Naka, Yoshifumi

AU - Yamashita, Toru

AU - Mancini, Donna M.

PY - 2012/3

Y1 - 2012/3

N2 - BACKGROUND AND PURPOSE-: Stroke is a major adverse event after left ventricular assist device (LVAD) surgery. The purpose of this study was to describe differences in hemispheric distribution of stroke in LVAD patients. METHODS-: We reviewed 317 consecutive patients who underwent LVAD surgery between November 2000 and July 2011. Stroke during LVAD support was analyzed. RESULTS-: In total, 46 strokes occurred at 76.0±96.8 days postoperatively. Among the 46 strokes, 27 events (58.7%) occurred in right hemisphere, 13 events (28.2%) in the left hemisphere, 3 events (8.7%) occurred bilaterally, and 2 events (4.3%) were vertebrobasilar lesions. The right hemispheric stroke was significantly more common in patients with postoperative infection compared with left hemispheric events. CONCLUSIONS-: Stroke after LVAD implantation has a right hemispheric predominance. This finding suggests LVAD-related thrombus in the setting of infection and/or the anatomic configuration of LVAD outflow cannula-ascending aorta anastomosis to be highly associated with stroke after LVAD surgery.

AB - BACKGROUND AND PURPOSE-: Stroke is a major adverse event after left ventricular assist device (LVAD) surgery. The purpose of this study was to describe differences in hemispheric distribution of stroke in LVAD patients. METHODS-: We reviewed 317 consecutive patients who underwent LVAD surgery between November 2000 and July 2011. Stroke during LVAD support was analyzed. RESULTS-: In total, 46 strokes occurred at 76.0±96.8 days postoperatively. Among the 46 strokes, 27 events (58.7%) occurred in right hemisphere, 13 events (28.2%) in the left hemisphere, 3 events (8.7%) occurred bilaterally, and 2 events (4.3%) were vertebrobasilar lesions. The right hemispheric stroke was significantly more common in patients with postoperative infection compared with left hemispheric events. CONCLUSIONS-: Stroke after LVAD implantation has a right hemispheric predominance. This finding suggests LVAD-related thrombus in the setting of infection and/or the anatomic configuration of LVAD outflow cannula-ascending aorta anastomosis to be highly associated with stroke after LVAD surgery.

KW - acute stroke

KW - cardiac surgery

KW - infectious disease

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Asymmetric pattern of cerebrovascular lesions in patients after left ventricular assist device implantation

Abstract

Keywords

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