Asymmetric Synthesis of Axinellamines A and B

Zhiqiang Ma, Xiao Wang, Yuyong Ma, Chuo Chen

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Axinellamines A and B are broad-spectrum antibacterial pyrrole-imidazole alkaloids that have a complex polycyclic skeleton. A new asymmetric synthesis of these marine sponge metabolites is described herein, featuring an oxidative rearrangement and an anchimeric chlorination reaction.

Original languageEnglish (US)
Pages (from-to)4763-4766
Number of pages4
JournalAngewandte Chemie - International Edition
Volume55
Issue number15
DOIs
StatePublished - Apr 4 2016

Keywords

  • alkaloids
  • anchimeric assistance
  • axinellamines
  • natural products
  • total synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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