@article{90ceaeea9ef640a7bbc55f1cc6ed1414,
title = "Asymmetric synthesis of ibuprofen via diastereoselective alkylation of a homochiral N-acylbornanesultam",
abstract = "A very short, 4 step synthesis of 2-(4-isobutylphenyl)propionic acid (ibuprofen) was achieved in 57% overall. yield, using a highly diastereoselective alkylation of the chiral enolate derived from N-(4-isobutylphenyl)acetyl bornanesultam as a key step.",
author = "Wolfgang Oppolzer and Stephane Rosset and {De Brabander}, Jef",
note = "Funding Information: Financial support of this work by the Swiss National Science Foundation, Sandoz Pharma Ltd, Basel and Givaudan-Roure AG, Dtibendorf, is gratefully acknowledged. We thank Mr. J. P. Saulnier, Mr. A. Pinto and Mrs. D. Klink for NMR and MS measurements.",
year = "1997",
month = mar,
day = "3",
doi = "10.1016/S0040-4039(97)00148-2",
language = "English (US)",
volume = "38",
pages = "1539--1540",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "9",
}