(equation presented) The title compound, a potent protein phosphatase inhibitor and anticancer agent, was prepared by an efficient, multiconvergent asymmetric synthesis. Key transformations include a ring forming olefin metathesis leading to the α,β-unsaturated lactone and creation of the triene moiety via Suzuki cross-coupling.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry