Asymmetric total synthesis of (+)-fostriecin

Y. Krishna Reddy, J R Falck

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

(equation presented) The title compound, a potent protein phosphatase inhibitor and anticancer agent, was prepared by an efficient, multiconvergent asymmetric synthesis. Key transformations include a ring forming olefin metathesis leading to the α,β-unsaturated lactone and creation of the triene moiety via Suzuki cross-coupling.

Original languageEnglish (US)
Pages (from-to)969-971
Number of pages3
JournalOrganic Letters
Volume4
Issue number6
DOIs
StatePublished - Mar 21 2002

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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