Atherogenic low density lipoprotein phenotype in long-term survivors of childhood acute lymphoblastic leukemia

Jyoti Malhotra, Emily S. Tonorezos, Marina Rozenberg, Gloria L. Vega, Charles A. Sklar, Joanne Chou, Chaya S. Moskowitz, Debra A. Eshelman-Kent, Peter Janiszewski, Robert Ross, Kevin C. Oeffinger

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Survivors of childhood acute lymphoblastic leukemia (ALL) have an increased risk of cardiovascular disease. Small density lipoproteins are atherogenic but have not been studied in this population. We conducted a cross-sectional analysis of 110 ALL survivors (mean age, 24.3 years) to determine prevalence of small dense LDL (pattern B) phenotype in ALL survivors and identify associated factors. Lipid subfractions were measured using Vertical Auto Profile-II. Participants with greater than 50% of LDL-cholesterol (LDL-c) in small dense LDL fractions (LDL3+4) were classified as LDL pattern B. Visceral and subcutaneous adipose tissue (VAT, SAT) volumes were also measured by computed tomography. While the mean LDL-c level of ALL survivors was 108.7 ± 26.8 mg/dl, 36% (40/110) of survivors had atherogenic LDL pattern B. This pattern was more common in males (26/47; 55%) than in females (14/63; 22%, P = 0.001) and more common in survivors treated with cranial radiotherapy (15/33; 45%) than in those who were treated with chemotherapy alone (25/77; 33%; P = 0.04, adjusted for age, gender, history of hypertension, and smoking history). VAT was associated with atherogenic lipids: LDL pattern B and LDL3+4 levels. This association was independent of other measures of body fat. We conclude that a substantial proportion of ALL survivors had an atherogenic LDL phenotype despite normal mean LDL-c levels. An atherogenic LDL phenotype may contribute to the increase in cardiovascular mortality and morbidity in this population.

Original languageEnglish (US)
Pages (from-to)2747-2754
Number of pages8
JournalJournal of Lipid Research
Volume53
Issue number12
DOIs
StatePublished - Dec 2012

Fingerprint

Precursor Cell Lymphoblastic Leukemia-Lymphoma
LDL Lipoproteins
Survivors
Phenotype
LDL Cholesterol
Lipids
Chemotherapy
Intra-Abdominal Fat
Subcutaneous Fat
Radiotherapy
oxidized low density lipoprotein
Population
Lipoproteins
Tomography
Adipose Tissue
Cardiovascular Diseases
Cross-Sectional Studies
Smoking
History
Fats

Keywords

  • Cancer
  • Dyslipidemias
  • LDL subfractions
  • Lipids
  • Lipoproteins

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Endocrinology

Cite this

Malhotra, J., Tonorezos, E. S., Rozenberg, M., Vega, G. L., Sklar, C. A., Chou, J., ... Oeffinger, K. C. (2012). Atherogenic low density lipoprotein phenotype in long-term survivors of childhood acute lymphoblastic leukemia. Journal of Lipid Research, 53(12), 2747-2754. https://doi.org/10.1194/jlr.P029785

Atherogenic low density lipoprotein phenotype in long-term survivors of childhood acute lymphoblastic leukemia. / Malhotra, Jyoti; Tonorezos, Emily S.; Rozenberg, Marina; Vega, Gloria L.; Sklar, Charles A.; Chou, Joanne; Moskowitz, Chaya S.; Eshelman-Kent, Debra A.; Janiszewski, Peter; Ross, Robert; Oeffinger, Kevin C.

In: Journal of Lipid Research, Vol. 53, No. 12, 12.2012, p. 2747-2754.

Research output: Contribution to journalArticle

Malhotra, J, Tonorezos, ES, Rozenberg, M, Vega, GL, Sklar, CA, Chou, J, Moskowitz, CS, Eshelman-Kent, DA, Janiszewski, P, Ross, R & Oeffinger, KC 2012, 'Atherogenic low density lipoprotein phenotype in long-term survivors of childhood acute lymphoblastic leukemia', Journal of Lipid Research, vol. 53, no. 12, pp. 2747-2754. https://doi.org/10.1194/jlr.P029785
Malhotra, Jyoti ; Tonorezos, Emily S. ; Rozenberg, Marina ; Vega, Gloria L. ; Sklar, Charles A. ; Chou, Joanne ; Moskowitz, Chaya S. ; Eshelman-Kent, Debra A. ; Janiszewski, Peter ; Ross, Robert ; Oeffinger, Kevin C. / Atherogenic low density lipoprotein phenotype in long-term survivors of childhood acute lymphoblastic leukemia. In: Journal of Lipid Research. 2012 ; Vol. 53, No. 12. pp. 2747-2754.
@article{ebfb4ac7cd8c497aaa356e7512cf4e95,
title = "Atherogenic low density lipoprotein phenotype in long-term survivors of childhood acute lymphoblastic leukemia",
abstract = "Survivors of childhood acute lymphoblastic leukemia (ALL) have an increased risk of cardiovascular disease. Small density lipoproteins are atherogenic but have not been studied in this population. We conducted a cross-sectional analysis of 110 ALL survivors (mean age, 24.3 years) to determine prevalence of small dense LDL (pattern B) phenotype in ALL survivors and identify associated factors. Lipid subfractions were measured using Vertical Auto Profile-II. Participants with greater than 50{\%} of LDL-cholesterol (LDL-c) in small dense LDL fractions (LDL3+4) were classified as LDL pattern B. Visceral and subcutaneous adipose tissue (VAT, SAT) volumes were also measured by computed tomography. While the mean LDL-c level of ALL survivors was 108.7 ± 26.8 mg/dl, 36{\%} (40/110) of survivors had atherogenic LDL pattern B. This pattern was more common in males (26/47; 55{\%}) than in females (14/63; 22{\%}, P = 0.001) and more common in survivors treated with cranial radiotherapy (15/33; 45{\%}) than in those who were treated with chemotherapy alone (25/77; 33{\%}; P = 0.04, adjusted for age, gender, history of hypertension, and smoking history). VAT was associated with atherogenic lipids: LDL pattern B and LDL3+4 levels. This association was independent of other measures of body fat. We conclude that a substantial proportion of ALL survivors had an atherogenic LDL phenotype despite normal mean LDL-c levels. An atherogenic LDL phenotype may contribute to the increase in cardiovascular mortality and morbidity in this population.",
keywords = "Cancer, Dyslipidemias, LDL subfractions, Lipids, Lipoproteins",
author = "Jyoti Malhotra and Tonorezos, {Emily S.} and Marina Rozenberg and Vega, {Gloria L.} and Sklar, {Charles A.} and Joanne Chou and Moskowitz, {Chaya S.} and Eshelman-Kent, {Debra A.} and Peter Janiszewski and Robert Ross and Oeffinger, {Kevin C.}",
year = "2012",
month = "12",
doi = "10.1194/jlr.P029785",
language = "English (US)",
volume = "53",
pages = "2747--2754",
journal = "Journal of Lipid Research",
issn = "0022-2275",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "12",

}

TY - JOUR

T1 - Atherogenic low density lipoprotein phenotype in long-term survivors of childhood acute lymphoblastic leukemia

AU - Malhotra, Jyoti

AU - Tonorezos, Emily S.

AU - Rozenberg, Marina

AU - Vega, Gloria L.

AU - Sklar, Charles A.

AU - Chou, Joanne

AU - Moskowitz, Chaya S.

AU - Eshelman-Kent, Debra A.

AU - Janiszewski, Peter

AU - Ross, Robert

AU - Oeffinger, Kevin C.

PY - 2012/12

Y1 - 2012/12

N2 - Survivors of childhood acute lymphoblastic leukemia (ALL) have an increased risk of cardiovascular disease. Small density lipoproteins are atherogenic but have not been studied in this population. We conducted a cross-sectional analysis of 110 ALL survivors (mean age, 24.3 years) to determine prevalence of small dense LDL (pattern B) phenotype in ALL survivors and identify associated factors. Lipid subfractions were measured using Vertical Auto Profile-II. Participants with greater than 50% of LDL-cholesterol (LDL-c) in small dense LDL fractions (LDL3+4) were classified as LDL pattern B. Visceral and subcutaneous adipose tissue (VAT, SAT) volumes were also measured by computed tomography. While the mean LDL-c level of ALL survivors was 108.7 ± 26.8 mg/dl, 36% (40/110) of survivors had atherogenic LDL pattern B. This pattern was more common in males (26/47; 55%) than in females (14/63; 22%, P = 0.001) and more common in survivors treated with cranial radiotherapy (15/33; 45%) than in those who were treated with chemotherapy alone (25/77; 33%; P = 0.04, adjusted for age, gender, history of hypertension, and smoking history). VAT was associated with atherogenic lipids: LDL pattern B and LDL3+4 levels. This association was independent of other measures of body fat. We conclude that a substantial proportion of ALL survivors had an atherogenic LDL phenotype despite normal mean LDL-c levels. An atherogenic LDL phenotype may contribute to the increase in cardiovascular mortality and morbidity in this population.

AB - Survivors of childhood acute lymphoblastic leukemia (ALL) have an increased risk of cardiovascular disease. Small density lipoproteins are atherogenic but have not been studied in this population. We conducted a cross-sectional analysis of 110 ALL survivors (mean age, 24.3 years) to determine prevalence of small dense LDL (pattern B) phenotype in ALL survivors and identify associated factors. Lipid subfractions were measured using Vertical Auto Profile-II. Participants with greater than 50% of LDL-cholesterol (LDL-c) in small dense LDL fractions (LDL3+4) were classified as LDL pattern B. Visceral and subcutaneous adipose tissue (VAT, SAT) volumes were also measured by computed tomography. While the mean LDL-c level of ALL survivors was 108.7 ± 26.8 mg/dl, 36% (40/110) of survivors had atherogenic LDL pattern B. This pattern was more common in males (26/47; 55%) than in females (14/63; 22%, P = 0.001) and more common in survivors treated with cranial radiotherapy (15/33; 45%) than in those who were treated with chemotherapy alone (25/77; 33%; P = 0.04, adjusted for age, gender, history of hypertension, and smoking history). VAT was associated with atherogenic lipids: LDL pattern B and LDL3+4 levels. This association was independent of other measures of body fat. We conclude that a substantial proportion of ALL survivors had an atherogenic LDL phenotype despite normal mean LDL-c levels. An atherogenic LDL phenotype may contribute to the increase in cardiovascular mortality and morbidity in this population.

KW - Cancer

KW - Dyslipidemias

KW - LDL subfractions

KW - Lipids

KW - Lipoproteins

UR - http://www.scopus.com/inward/record.url?scp=84869020792&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869020792&partnerID=8YFLogxK

U2 - 10.1194/jlr.P029785

DO - 10.1194/jlr.P029785

M3 - Article

C2 - 22984143

AN - SCOPUS:84869020792

VL - 53

SP - 2747

EP - 2754

JO - Journal of Lipid Research

JF - Journal of Lipid Research

SN - 0022-2275

IS - 12

ER -