Atrial natriuretic peptide and acute changes in central blood volume by hyperthermia in healthy humans

Thomas Wiis Vogelsang, Jens Marving, Craig G. Crandall, Chad Wilson, Chie C. Yoshiga, Niels H. Secher, Birger Hesse, Andreas Kjaer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Hyperthermia induces vasodilatation that reduces central blood volume (CBV), central venous pressure (CVP) and mean arterial pressure (MAP). Inhibition of atrial natriuretic peptide (ANP) could be a relevant homeostatic defense mechanism during hyperthermia with a decrease in CBV. The present study evaluated how changes in plasma ANP reflect the changes in CBV during hyperthermia. Methods: Ten healthy subjects provided with a water perfused body suit increased body core temperature 1 °C. In situ labeled autologous red blood cells were used to measure the CBV with a gamma camera. Regions of interest were traced manually on the images of the whole body blood pool scans. Two measures of CBV were used: Heart/whole body ratio and thorax/whole body ratio. CVP and MAP were recorded. Arterial (ANP art) and venous plasma ANP were determined by radioimmunoassay. Results: The ratio thorax/whole body and heart/whole body decreased 7 % and 11 %, respectively (p<0.001). MAP and CVP decreased during hyperthermia by 6.8 and 5.0 mmHg, respectively (p<0.05; p<0.001). Changes in both thorax/whole body (R=0.80; p<0.01) and heart/whole body ratios (R=0.78; p<0.01) were correlated with changes in ANP art. However, there was no correlation between venous ANP and changes in CBV, nor between ANP art and MAP or CVP. Conclusion: Arterial but not venous plasma concentration of ANP, is correlated to changes in CBV, but not to pressures. We suggest that plasma ANP art may be used as a surrogate marker of acute CBV changes.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalOpen Neuroendocrinology Journal
Volume5
Issue number1
DOIs
StatePublished - 2012

Fingerprint

Atrial Natriuretic Factor
Blood Volume
Fever
Central Venous Pressure
Art
Arterial Pressure
Thorax
Gamma Cameras
Body Water
Body Image
Body Temperature
Vasodilation
Radioimmunoassay
Healthy Volunteers
Erythrocytes
Biomarkers
Pressure

Keywords

  • ANP
  • Blood pool imaging
  • Central blood volume
  • Heating
  • Natriuretic peptides
  • Nuclear medicine

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Endocrinology, Diabetes and Metabolism

Cite this

Atrial natriuretic peptide and acute changes in central blood volume by hyperthermia in healthy humans. / Vogelsang, Thomas Wiis; Marving, Jens; Crandall, Craig G.; Wilson, Chad; Yoshiga, Chie C.; Secher, Niels H.; Hesse, Birger; Kjaer, Andreas.

In: Open Neuroendocrinology Journal, Vol. 5, No. 1, 2012, p. 1-4.

Research output: Contribution to journalArticle

Vogelsang, Thomas Wiis ; Marving, Jens ; Crandall, Craig G. ; Wilson, Chad ; Yoshiga, Chie C. ; Secher, Niels H. ; Hesse, Birger ; Kjaer, Andreas. / Atrial natriuretic peptide and acute changes in central blood volume by hyperthermia in healthy humans. In: Open Neuroendocrinology Journal. 2012 ; Vol. 5, No. 1. pp. 1-4.
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abstract = "Background: Hyperthermia induces vasodilatation that reduces central blood volume (CBV), central venous pressure (CVP) and mean arterial pressure (MAP). Inhibition of atrial natriuretic peptide (ANP) could be a relevant homeostatic defense mechanism during hyperthermia with a decrease in CBV. The present study evaluated how changes in plasma ANP reflect the changes in CBV during hyperthermia. Methods: Ten healthy subjects provided with a water perfused body suit increased body core temperature 1 °C. In situ labeled autologous red blood cells were used to measure the CBV with a gamma camera. Regions of interest were traced manually on the images of the whole body blood pool scans. Two measures of CBV were used: Heart/whole body ratio and thorax/whole body ratio. CVP and MAP were recorded. Arterial (ANP art) and venous plasma ANP were determined by radioimmunoassay. Results: The ratio thorax/whole body and heart/whole body decreased 7 {\%} and 11 {\%}, respectively (p<0.001). MAP and CVP decreased during hyperthermia by 6.8 and 5.0 mmHg, respectively (p<0.05; p<0.001). Changes in both thorax/whole body (R=0.80; p<0.01) and heart/whole body ratios (R=0.78; p<0.01) were correlated with changes in ANP art. However, there was no correlation between venous ANP and changes in CBV, nor between ANP art and MAP or CVP. Conclusion: Arterial but not venous plasma concentration of ANP, is correlated to changes in CBV, but not to pressures. We suggest that plasma ANP art may be used as a surrogate marker of acute CBV changes.",
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AU - Vogelsang, Thomas Wiis

AU - Marving, Jens

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AU - Wilson, Chad

AU - Yoshiga, Chie C.

AU - Secher, Niels H.

AU - Hesse, Birger

AU - Kjaer, Andreas

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N2 - Background: Hyperthermia induces vasodilatation that reduces central blood volume (CBV), central venous pressure (CVP) and mean arterial pressure (MAP). Inhibition of atrial natriuretic peptide (ANP) could be a relevant homeostatic defense mechanism during hyperthermia with a decrease in CBV. The present study evaluated how changes in plasma ANP reflect the changes in CBV during hyperthermia. Methods: Ten healthy subjects provided with a water perfused body suit increased body core temperature 1 °C. In situ labeled autologous red blood cells were used to measure the CBV with a gamma camera. Regions of interest were traced manually on the images of the whole body blood pool scans. Two measures of CBV were used: Heart/whole body ratio and thorax/whole body ratio. CVP and MAP were recorded. Arterial (ANP art) and venous plasma ANP were determined by radioimmunoassay. Results: The ratio thorax/whole body and heart/whole body decreased 7 % and 11 %, respectively (p<0.001). MAP and CVP decreased during hyperthermia by 6.8 and 5.0 mmHg, respectively (p<0.05; p<0.001). Changes in both thorax/whole body (R=0.80; p<0.01) and heart/whole body ratios (R=0.78; p<0.01) were correlated with changes in ANP art. However, there was no correlation between venous ANP and changes in CBV, nor between ANP art and MAP or CVP. Conclusion: Arterial but not venous plasma concentration of ANP, is correlated to changes in CBV, but not to pressures. We suggest that plasma ANP art may be used as a surrogate marker of acute CBV changes.

AB - Background: Hyperthermia induces vasodilatation that reduces central blood volume (CBV), central venous pressure (CVP) and mean arterial pressure (MAP). Inhibition of atrial natriuretic peptide (ANP) could be a relevant homeostatic defense mechanism during hyperthermia with a decrease in CBV. The present study evaluated how changes in plasma ANP reflect the changes in CBV during hyperthermia. Methods: Ten healthy subjects provided with a water perfused body suit increased body core temperature 1 °C. In situ labeled autologous red blood cells were used to measure the CBV with a gamma camera. Regions of interest were traced manually on the images of the whole body blood pool scans. Two measures of CBV were used: Heart/whole body ratio and thorax/whole body ratio. CVP and MAP were recorded. Arterial (ANP art) and venous plasma ANP were determined by radioimmunoassay. Results: The ratio thorax/whole body and heart/whole body decreased 7 % and 11 %, respectively (p<0.001). MAP and CVP decreased during hyperthermia by 6.8 and 5.0 mmHg, respectively (p<0.05; p<0.001). Changes in both thorax/whole body (R=0.80; p<0.01) and heart/whole body ratios (R=0.78; p<0.01) were correlated with changes in ANP art. However, there was no correlation between venous ANP and changes in CBV, nor between ANP art and MAP or CVP. Conclusion: Arterial but not venous plasma concentration of ANP, is correlated to changes in CBV, but not to pressures. We suggest that plasma ANP art may be used as a surrogate marker of acute CBV changes.

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