Atrial natriuretic peptide, vasoactive intestinal peptide, and skin blood flow during heat stress in humans

D. L. Kellogo, P. E. Pergola, R. E. Shada, G. G. Crandall, D. E. Solomon, J. M. Johnson

Research output: Contribution to journalArticle

Abstract

Active vasodilation effects most of the reflex increase in skin blood flow during heat stress by release of acetylcholine and an unknown cotransmitter from cutaneous sympathetic nerves. Among possible cotransmitters are atrial natriuretic peptide(ANP) and vasoactive intestinal peptide(VIP) which are found in efferent nerves innervating cutaneous blood vessels. To examine whether these neuropeptides could be the co-transmitter that effects active vasodilation, we measured plasma ANP and VlP(radioimmunoassay) from superficial forearm veins in normothermia, during hyperthermia, and after recovery from whole body heat stress(water perfused suits). Skin blood flow was simultaneously monitored by laser-Doppler flowmetry(LDF) in each of 5 subjects. Internal temperature and blood pressure(Finapres) were measured. Cutaneous vascular conductance was calculated(CVC=LDF/MAP). During normothermia, plasma levels of ANP and VIP were 57±3 and 16±4pg/ml respectively. During heat stress, ANP rose to 71±4pg/ml (p<0.05), but VIP was not significantly changed (18±7pg/ml, p>0.05). During hyperthermia, CVC rose to an average of 515±102% of normothermic levels(p<0.05). After recovery from heat stress, CVC returned to normothermic levels(p>0.05). ANP also returned to normothermic levels(50±6pg/ml, p>0.05 vs. normo, p<0.05 vs. hyperthermia). VIP remained unchanged(16±4pg/ml, p>0.05). Our finding that ANP increases during heat stress, but that VIP levels do not, suggests ANP could mediate cutaneous active vasodilation.

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - 1996

Fingerprint

atrial natriuretic peptide
vasoactive intestinal peptide
Vasoactive Intestinal Peptide
Atrial Natriuretic Factor
skin (animal)
blood flow
heat stress
Skin
Blood
Hot Temperature
Heat transfer
vasodilation
Vasodilation
Laser-Doppler Flowmetry
blood vessels
fever
lasers
Blood Vessels
nerve tissue
Rosa

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Kellogo, D. L., Pergola, P. E., Shada, R. E., Crandall, G. G., Solomon, D. E., & Johnson, J. M. (1996). Atrial natriuretic peptide, vasoactive intestinal peptide, and skin blood flow during heat stress in humans. FASEB Journal, 10(3).

Atrial natriuretic peptide, vasoactive intestinal peptide, and skin blood flow during heat stress in humans. / Kellogo, D. L.; Pergola, P. E.; Shada, R. E.; Crandall, G. G.; Solomon, D. E.; Johnson, J. M.

In: FASEB Journal, Vol. 10, No. 3, 1996.

Research output: Contribution to journalArticle

Kellogo, DL, Pergola, PE, Shada, RE, Crandall, GG, Solomon, DE & Johnson, JM 1996, 'Atrial natriuretic peptide, vasoactive intestinal peptide, and skin blood flow during heat stress in humans', FASEB Journal, vol. 10, no. 3.
Kellogo, D. L. ; Pergola, P. E. ; Shada, R. E. ; Crandall, G. G. ; Solomon, D. E. ; Johnson, J. M. / Atrial natriuretic peptide, vasoactive intestinal peptide, and skin blood flow during heat stress in humans. In: FASEB Journal. 1996 ; Vol. 10, No. 3.
@article{c8692795d37543aa86b5a7a2aab59942,
title = "Atrial natriuretic peptide, vasoactive intestinal peptide, and skin blood flow during heat stress in humans",
abstract = "Active vasodilation effects most of the reflex increase in skin blood flow during heat stress by release of acetylcholine and an unknown cotransmitter from cutaneous sympathetic nerves. Among possible cotransmitters are atrial natriuretic peptide(ANP) and vasoactive intestinal peptide(VIP) which are found in efferent nerves innervating cutaneous blood vessels. To examine whether these neuropeptides could be the co-transmitter that effects active vasodilation, we measured plasma ANP and VlP(radioimmunoassay) from superficial forearm veins in normothermia, during hyperthermia, and after recovery from whole body heat stress(water perfused suits). Skin blood flow was simultaneously monitored by laser-Doppler flowmetry(LDF) in each of 5 subjects. Internal temperature and blood pressure(Finapres) were measured. Cutaneous vascular conductance was calculated(CVC=LDF/MAP). During normothermia, plasma levels of ANP and VIP were 57±3 and 16±4pg/ml respectively. During heat stress, ANP rose to 71±4pg/ml (p<0.05), but VIP was not significantly changed (18±7pg/ml, p>0.05). During hyperthermia, CVC rose to an average of 515±102{\%} of normothermic levels(p<0.05). After recovery from heat stress, CVC returned to normothermic levels(p>0.05). ANP also returned to normothermic levels(50±6pg/ml, p>0.05 vs. normo, p<0.05 vs. hyperthermia). VIP remained unchanged(16±4pg/ml, p>0.05). Our finding that ANP increases during heat stress, but that VIP levels do not, suggests ANP could mediate cutaneous active vasodilation.",
author = "Kellogo, {D. L.} and Pergola, {P. E.} and Shada, {R. E.} and Crandall, {G. G.} and Solomon, {D. E.} and Johnson, {J. M.}",
year = "1996",
language = "English (US)",
volume = "10",
journal = "FASEB Journal",
issn = "0892-6638",
publisher = "FASEB",
number = "3",

}

TY - JOUR

T1 - Atrial natriuretic peptide, vasoactive intestinal peptide, and skin blood flow during heat stress in humans

AU - Kellogo, D. L.

AU - Pergola, P. E.

AU - Shada, R. E.

AU - Crandall, G. G.

AU - Solomon, D. E.

AU - Johnson, J. M.

PY - 1996

Y1 - 1996

N2 - Active vasodilation effects most of the reflex increase in skin blood flow during heat stress by release of acetylcholine and an unknown cotransmitter from cutaneous sympathetic nerves. Among possible cotransmitters are atrial natriuretic peptide(ANP) and vasoactive intestinal peptide(VIP) which are found in efferent nerves innervating cutaneous blood vessels. To examine whether these neuropeptides could be the co-transmitter that effects active vasodilation, we measured plasma ANP and VlP(radioimmunoassay) from superficial forearm veins in normothermia, during hyperthermia, and after recovery from whole body heat stress(water perfused suits). Skin blood flow was simultaneously monitored by laser-Doppler flowmetry(LDF) in each of 5 subjects. Internal temperature and blood pressure(Finapres) were measured. Cutaneous vascular conductance was calculated(CVC=LDF/MAP). During normothermia, plasma levels of ANP and VIP were 57±3 and 16±4pg/ml respectively. During heat stress, ANP rose to 71±4pg/ml (p<0.05), but VIP was not significantly changed (18±7pg/ml, p>0.05). During hyperthermia, CVC rose to an average of 515±102% of normothermic levels(p<0.05). After recovery from heat stress, CVC returned to normothermic levels(p>0.05). ANP also returned to normothermic levels(50±6pg/ml, p>0.05 vs. normo, p<0.05 vs. hyperthermia). VIP remained unchanged(16±4pg/ml, p>0.05). Our finding that ANP increases during heat stress, but that VIP levels do not, suggests ANP could mediate cutaneous active vasodilation.

AB - Active vasodilation effects most of the reflex increase in skin blood flow during heat stress by release of acetylcholine and an unknown cotransmitter from cutaneous sympathetic nerves. Among possible cotransmitters are atrial natriuretic peptide(ANP) and vasoactive intestinal peptide(VIP) which are found in efferent nerves innervating cutaneous blood vessels. To examine whether these neuropeptides could be the co-transmitter that effects active vasodilation, we measured plasma ANP and VlP(radioimmunoassay) from superficial forearm veins in normothermia, during hyperthermia, and after recovery from whole body heat stress(water perfused suits). Skin blood flow was simultaneously monitored by laser-Doppler flowmetry(LDF) in each of 5 subjects. Internal temperature and blood pressure(Finapres) were measured. Cutaneous vascular conductance was calculated(CVC=LDF/MAP). During normothermia, plasma levels of ANP and VIP were 57±3 and 16±4pg/ml respectively. During heat stress, ANP rose to 71±4pg/ml (p<0.05), but VIP was not significantly changed (18±7pg/ml, p>0.05). During hyperthermia, CVC rose to an average of 515±102% of normothermic levels(p<0.05). After recovery from heat stress, CVC returned to normothermic levels(p>0.05). ANP also returned to normothermic levels(50±6pg/ml, p>0.05 vs. normo, p<0.05 vs. hyperthermia). VIP remained unchanged(16±4pg/ml, p>0.05). Our finding that ANP increases during heat stress, but that VIP levels do not, suggests ANP could mediate cutaneous active vasodilation.

UR - http://www.scopus.com/inward/record.url?scp=33748960449&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748960449&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33748960449

VL - 10

JO - FASEB Journal

JF - FASEB Journal

SN - 0892-6638

IS - 3

ER -