ATRP in the design of functional materials for biomedical applications

Daniel J. Siegwart, Jung Kwon Oh, Krzysztof Matyjaszewski

Research output: Contribution to journalReview articlepeer-review

388 Scopus citations

Abstract

Atom Transfer Radical Polymerization (ATRP) is an effective technique for the design and preparation of multifunctional, nanostructured materials for a variety of applications in biology and medicine. ATRP enables precise control over macromolecular structure, order, and functionality, which are important considerations for emerging biomedical designs. This article reviews recent advances in the preparation of polymer-based nanomaterials using ATRP, including polymer bioconjugates, block copolymer-based drug delivery systems, cross-linked microgels/nanogels, diagnostic and imaging platforms, tissue engineering hydrogels, and degradable polymers. It is envisioned that precise engineering at the molecular level will translate to tailored macroscopic physical properties, thus enabling control of the key elements for realized biomedical applications.

Original languageEnglish (US)
Pages (from-to)18-37
Number of pages20
JournalProgress in Polymer Science (Oxford)
Volume37
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • Atom Transfer Radical Polymerization (ATRP)
  • Bioactive surfaces
  • Bioconjugation
  • Biomaterials
  • Biomedical engineering
  • Block copolymers
  • Drug delivery
  • Functionality
  • Imaging
  • Nanogels
  • Nanoparticles
  • Polymer grafting
  • Polymeric micelles
  • Tissue engineering

ASJC Scopus subject areas

  • Ceramics and Composites
  • Surfaces and Interfaces
  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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