ATRP in the design of functional materials for biomedical applications

Daniel J. Siegwart, Jung Kwon Oh, Krzysztof Matyjaszewski

Research output: Contribution to journalArticle

363 Citations (Scopus)

Abstract

Atom Transfer Radical Polymerization (ATRP) is an effective technique for the design and preparation of multifunctional, nanostructured materials for a variety of applications in biology and medicine. ATRP enables precise control over macromolecular structure, order, and functionality, which are important considerations for emerging biomedical designs. This article reviews recent advances in the preparation of polymer-based nanomaterials using ATRP, including polymer bioconjugates, block copolymer-based drug delivery systems, cross-linked microgels/nanogels, diagnostic and imaging platforms, tissue engineering hydrogels, and degradable polymers. It is envisioned that precise engineering at the molecular level will translate to tailored macroscopic physical properties, thus enabling control of the key elements for realized biomedical applications.

Original languageEnglish (US)
Pages (from-to)18-37
Number of pages20
JournalProgress in Polymer Science (Oxford)
Volume37
Issue number1
DOIs
StatePublished - Jan 2012

Fingerprint

Functional materials
Atom transfer radical polymerization
polymerization
Nanostructured materials
Polymers
polymers
atoms
preparation
Hydrogels
tissue engineering
block copolymers
biology
medicine
Tissue engineering
Block copolymers
Medicine
emerging
delivery
drugs
platforms

Keywords

  • Atom Transfer Radical Polymerization (ATRP)
  • Bioactive surfaces
  • Bioconjugation
  • Biomaterials
  • Biomedical engineering
  • Block copolymers
  • Drug delivery
  • Functionality
  • Imaging
  • Nanogels
  • Nanoparticles
  • Polymer grafting
  • Polymeric micelles
  • Tissue engineering

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry
  • Polymers and Plastics
  • Organic Chemistry
  • Surfaces and Interfaces

Cite this

ATRP in the design of functional materials for biomedical applications. / Siegwart, Daniel J.; Oh, Jung Kwon; Matyjaszewski, Krzysztof.

In: Progress in Polymer Science (Oxford), Vol. 37, No. 1, 01.2012, p. 18-37.

Research output: Contribution to journalArticle

Siegwart, Daniel J. ; Oh, Jung Kwon ; Matyjaszewski, Krzysztof. / ATRP in the design of functional materials for biomedical applications. In: Progress in Polymer Science (Oxford). 2012 ; Vol. 37, No. 1. pp. 18-37.
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