ATRP in the design of functional materials for biomedical applications

Daniel J. Siegwart; Jung Kwon Oh; Krzysztof Matyjaszewski

doi:10.1016/j.progpolymsci.2011.08.001

ATRP in the design of functional materials for biomedical applications

Daniel J. Siegwart, Jung Kwon Oh, Krzysztof Matyjaszewski

Research output: Contribution to journal › Review article › peer-review

503 Scopus citations

Abstract

Atom Transfer Radical Polymerization (ATRP) is an effective technique for the design and preparation of multifunctional, nanostructured materials for a variety of applications in biology and medicine. ATRP enables precise control over macromolecular structure, order, and functionality, which are important considerations for emerging biomedical designs. This article reviews recent advances in the preparation of polymer-based nanomaterials using ATRP, including polymer bioconjugates, block copolymer-based drug delivery systems, cross-linked microgels/nanogels, diagnostic and imaging platforms, tissue engineering hydrogels, and degradable polymers. It is envisioned that precise engineering at the molecular level will translate to tailored macroscopic physical properties, thus enabling control of the key elements for realized biomedical applications.

Original language	English (US)
Pages (from-to)	18-37
Number of pages	20
Journal	Progress in Polymer Science (Oxford)
Volume	37
Issue number	1
DOIs	https://doi.org/10.1016/j.progpolymsci.2011.08.001
State	Published - Jan 2012

Keywords

Atom Transfer Radical Polymerization (ATRP)
Bioactive surfaces
Bioconjugation
Biomaterials
Biomedical engineering
Block copolymers
Drug delivery
Functionality
Imaging
Nanogels
Nanoparticles
Polymer grafting
Polymeric micelles
Tissue engineering

ASJC Scopus subject areas

Ceramics and Composites
Surfaces and Interfaces
Polymers and Plastics
Organic Chemistry
Materials Chemistry

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10.1016/j.progpolymsci.2011.08.001

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title = "ATRP in the design of functional materials for biomedical applications",

abstract = "Atom Transfer Radical Polymerization (ATRP) is an effective technique for the design and preparation of multifunctional, nanostructured materials for a variety of applications in biology and medicine. ATRP enables precise control over macromolecular structure, order, and functionality, which are important considerations for emerging biomedical designs. This article reviews recent advances in the preparation of polymer-based nanomaterials using ATRP, including polymer bioconjugates, block copolymer-based drug delivery systems, cross-linked microgels/nanogels, diagnostic and imaging platforms, tissue engineering hydrogels, and degradable polymers. It is envisioned that precise engineering at the molecular level will translate to tailored macroscopic physical properties, thus enabling control of the key elements for realized biomedical applications.",

keywords = "Atom Transfer Radical Polymerization (ATRP), Bioactive surfaces, Bioconjugation, Biomaterials, Biomedical engineering, Block copolymers, Drug delivery, Functionality, Imaging, Nanogels, Nanoparticles, Polymer grafting, Polymeric micelles, Tissue engineering",

author = "Siegwart, {Daniel J.} and Oh, {Jung Kwon} and Krzysztof Matyjaszewski",

note = "Funding Information: DJS was supported by a Ruth L. Kirschstein National Research Service Award (NRSA) for Individual Postdoctoral Fellows, award number F32EB011867 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) . The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIBIB or the National Institutes of Health (NIH). JKO is a Canada Research Chair (Tier II CRC) in Nanobioscience and greatly acknowledges financial support from a NSERC Canada Discovery Grant , a NSERC CRC Award, and Concordia University Start-up Funds. KM acknowledges support from the NSF ( DMR-09-69301 ) and the WCU (World Class University) program through the Korea Science and Engineering Foundation funded by the Ministry of Education, Science and Technology ( R33-10035-0 ). The authors also acknowledge the work of authors whose research could not be featured due to space constraints.",

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ATRP in the design of functional materials for biomedical applications

Abstract

Keywords

ASJC Scopus subject areas

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