Atypical depressive symptoms as a predictor of treatment response to exercise in Major Depressive Disorder

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5 Citations (Scopus)

Abstract

Effective treatment of Major Depressive Disorder (MDD) will require the development of alternative treatments and the ability for clinicians to match patients with the treatment likely to produce the greatest effect. We examined atypical depression subtype as a predictor of treatment response to aerobic exercise augmentation in persons with non-remitted MDD. Our results revealed a small-to-moderate effect, particularly in a group assigned to high-dose exercise (semi-partial eta-squared =0.0335, p=0.0735), indicating that those with atypical depression tended to have larger treatment response to exercise. Through this hypothesis-generating analysis, we indicate the need for research to examine depression subtype, along with other demographic, clinical and biological factors as predictors of treatment response to exercise.

Original languageEnglish (US)
Pages (from-to)156-158
Number of pages3
JournalJournal of Affective Disorders
Volume200
DOIs
StatePublished - Aug 1 2016

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Major Depressive Disorder
Exercise
Depression
Therapeutics
Aptitude
Biological Factors
Demography
Research

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

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title = "Atypical depressive symptoms as a predictor of treatment response to exercise in Major Depressive Disorder",
abstract = "Effective treatment of Major Depressive Disorder (MDD) will require the development of alternative treatments and the ability for clinicians to match patients with the treatment likely to produce the greatest effect. We examined atypical depression subtype as a predictor of treatment response to aerobic exercise augmentation in persons with non-remitted MDD. Our results revealed a small-to-moderate effect, particularly in a group assigned to high-dose exercise (semi-partial eta-squared =0.0335, p=0.0735), indicating that those with atypical depression tended to have larger treatment response to exercise. Through this hypothesis-generating analysis, we indicate the need for research to examine depression subtype, along with other demographic, clinical and biological factors as predictors of treatment response to exercise.",
author = "Rethorst, {Chad D.} and Jian Tu and Carmody, {Thomas J.} and Greer, {Tracy L.} and Trivedi, {Madhukar H.}",
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T1 - Atypical depressive symptoms as a predictor of treatment response to exercise in Major Depressive Disorder

AU - Rethorst, Chad D.

AU - Tu, Jian

AU - Carmody, Thomas J.

AU - Greer, Tracy L.

AU - Trivedi, Madhukar H.

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AB - Effective treatment of Major Depressive Disorder (MDD) will require the development of alternative treatments and the ability for clinicians to match patients with the treatment likely to produce the greatest effect. We examined atypical depression subtype as a predictor of treatment response to aerobic exercise augmentation in persons with non-remitted MDD. Our results revealed a small-to-moderate effect, particularly in a group assigned to high-dose exercise (semi-partial eta-squared =0.0335, p=0.0735), indicating that those with atypical depression tended to have larger treatment response to exercise. Through this hypothesis-generating analysis, we indicate the need for research to examine depression subtype, along with other demographic, clinical and biological factors as predictors of treatment response to exercise.

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