Auditory steady-state EEG response across the schizo-bipolar spectrum

David A. Parker, Jordan P. Hamm, Jennifer E. McDowell, Sarah K. Keedy, Elliot S. Gershon, Elena Ivleva, Godfrey D. Pearlson, Matcheri S. Keshavan, Carol A Tamminga, John A Sweeney, Brett A. Clementz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Deviant auditory steady-state responses (aSSRs)in the gamma range (30–90 Hz)may be translational biomarkers for schizophrenia (SZ). This study tests whether aSSR deviations are (i)specific to SZ across the psychosis dimension, (ii)specific to particular frequency bands, and (iii)present in bipolar I disorder without psychosis (BDNP). Methods: Beta (20-), low- (40-), and high-gamma (80-Hz)aSSRs were measured with EEG and compared across 113 SZ, 105 schizoaffective disorder (SAD), 99 bipolar disorder with psychosis (BDP), 68 BDNP, and 137 healthy comparison subjects (HC). Standard aSSR measures (single-trial power [STP]and inter-trial phase coherence [ITC]), as well as evoked responses to stimulus onsets/offsets and pre-stimulus power, were quantified. Multivariate canonical discriminant analysis was used to summarize variables that efficiently and maximally differentiated groups. Results: (i)Psychosis groups showed reduced responses on ITC 20 Hz, STP/ITC 40 Hz, STP/ITC 80 Hz, indicating dimensional reductions in aSSR across the psychosis spectrum not specific to aSSR frequency. For the 40- and 80-Hz ITCs there was greater reduction in SZ compared to SAD, possibly indexing cortical disruptions linked to psychosis without mood symptoms. (ii)All probands had elevated pre-stimulus power, possibly compromising neural entrainment to the steady-state stimuli. (iii)Onset/Offset and 80 Hz ITC responses were most important for group discrimination and showed dimensional reduction across the schizo-bipolar spectrum. Conclusions: Deviant aSSRs were found across the schizo-bipolar spectrum at multiple frequencies with psychosis status and severity linked to greatest reductions at low and high gamma.

Original languageEnglish (US)
JournalSchizophrenia Research
DOIs
StatePublished - Jan 1 2019

Fingerprint

Psychotic Disorders
Electroencephalography
Schizophrenia
Bipolar Disorder
Discriminant Analysis
Healthy Volunteers
Biomarkers
Power (Psychology)

Keywords

  • Auditory steady-state response
  • Bipolar disorder
  • EEG biomarkers
  • Gamma oscillations
  • Psychosis
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Parker, D. A., Hamm, J. P., McDowell, J. E., Keedy, S. K., Gershon, E. S., Ivleva, E., ... Clementz, B. A. (2019). Auditory steady-state EEG response across the schizo-bipolar spectrum. Schizophrenia Research. https://doi.org/10.1016/j.schres.2019.04.014

Auditory steady-state EEG response across the schizo-bipolar spectrum. / Parker, David A.; Hamm, Jordan P.; McDowell, Jennifer E.; Keedy, Sarah K.; Gershon, Elliot S.; Ivleva, Elena; Pearlson, Godfrey D.; Keshavan, Matcheri S.; Tamminga, Carol A; Sweeney, John A; Clementz, Brett A.

In: Schizophrenia Research, 01.01.2019.

Research output: Contribution to journalArticle

Parker, David A. ; Hamm, Jordan P. ; McDowell, Jennifer E. ; Keedy, Sarah K. ; Gershon, Elliot S. ; Ivleva, Elena ; Pearlson, Godfrey D. ; Keshavan, Matcheri S. ; Tamminga, Carol A ; Sweeney, John A ; Clementz, Brett A. / Auditory steady-state EEG response across the schizo-bipolar spectrum. In: Schizophrenia Research. 2019.
@article{6b28f51a6568465899fcac1214129bbb,
title = "Auditory steady-state EEG response across the schizo-bipolar spectrum",
abstract = "Deviant auditory steady-state responses (aSSRs)in the gamma range (30–90 Hz)may be translational biomarkers for schizophrenia (SZ). This study tests whether aSSR deviations are (i)specific to SZ across the psychosis dimension, (ii)specific to particular frequency bands, and (iii)present in bipolar I disorder without psychosis (BDNP). Methods: Beta (20-), low- (40-), and high-gamma (80-Hz)aSSRs were measured with EEG and compared across 113 SZ, 105 schizoaffective disorder (SAD), 99 bipolar disorder with psychosis (BDP), 68 BDNP, and 137 healthy comparison subjects (HC). Standard aSSR measures (single-trial power [STP]and inter-trial phase coherence [ITC]), as well as evoked responses to stimulus onsets/offsets and pre-stimulus power, were quantified. Multivariate canonical discriminant analysis was used to summarize variables that efficiently and maximally differentiated groups. Results: (i)Psychosis groups showed reduced responses on ITC 20 Hz, STP/ITC 40 Hz, STP/ITC 80 Hz, indicating dimensional reductions in aSSR across the psychosis spectrum not specific to aSSR frequency. For the 40- and 80-Hz ITCs there was greater reduction in SZ compared to SAD, possibly indexing cortical disruptions linked to psychosis without mood symptoms. (ii)All probands had elevated pre-stimulus power, possibly compromising neural entrainment to the steady-state stimuli. (iii)Onset/Offset and 80 Hz ITC responses were most important for group discrimination and showed dimensional reduction across the schizo-bipolar spectrum. Conclusions: Deviant aSSRs were found across the schizo-bipolar spectrum at multiple frequencies with psychosis status and severity linked to greatest reductions at low and high gamma.",
keywords = "Auditory steady-state response, Bipolar disorder, EEG biomarkers, Gamma oscillations, Psychosis, Schizophrenia",
author = "Parker, {David A.} and Hamm, {Jordan P.} and McDowell, {Jennifer E.} and Keedy, {Sarah K.} and Gershon, {Elliot S.} and Elena Ivleva and Pearlson, {Godfrey D.} and Keshavan, {Matcheri S.} and Tamminga, {Carol A} and Sweeney, {John A} and Clementz, {Brett A.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.schres.2019.04.014",
language = "English (US)",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",

}

TY - JOUR

T1 - Auditory steady-state EEG response across the schizo-bipolar spectrum

AU - Parker, David A.

AU - Hamm, Jordan P.

AU - McDowell, Jennifer E.

AU - Keedy, Sarah K.

AU - Gershon, Elliot S.

AU - Ivleva, Elena

AU - Pearlson, Godfrey D.

AU - Keshavan, Matcheri S.

AU - Tamminga, Carol A

AU - Sweeney, John A

AU - Clementz, Brett A.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Deviant auditory steady-state responses (aSSRs)in the gamma range (30–90 Hz)may be translational biomarkers for schizophrenia (SZ). This study tests whether aSSR deviations are (i)specific to SZ across the psychosis dimension, (ii)specific to particular frequency bands, and (iii)present in bipolar I disorder without psychosis (BDNP). Methods: Beta (20-), low- (40-), and high-gamma (80-Hz)aSSRs were measured with EEG and compared across 113 SZ, 105 schizoaffective disorder (SAD), 99 bipolar disorder with psychosis (BDP), 68 BDNP, and 137 healthy comparison subjects (HC). Standard aSSR measures (single-trial power [STP]and inter-trial phase coherence [ITC]), as well as evoked responses to stimulus onsets/offsets and pre-stimulus power, were quantified. Multivariate canonical discriminant analysis was used to summarize variables that efficiently and maximally differentiated groups. Results: (i)Psychosis groups showed reduced responses on ITC 20 Hz, STP/ITC 40 Hz, STP/ITC 80 Hz, indicating dimensional reductions in aSSR across the psychosis spectrum not specific to aSSR frequency. For the 40- and 80-Hz ITCs there was greater reduction in SZ compared to SAD, possibly indexing cortical disruptions linked to psychosis without mood symptoms. (ii)All probands had elevated pre-stimulus power, possibly compromising neural entrainment to the steady-state stimuli. (iii)Onset/Offset and 80 Hz ITC responses were most important for group discrimination and showed dimensional reduction across the schizo-bipolar spectrum. Conclusions: Deviant aSSRs were found across the schizo-bipolar spectrum at multiple frequencies with psychosis status and severity linked to greatest reductions at low and high gamma.

AB - Deviant auditory steady-state responses (aSSRs)in the gamma range (30–90 Hz)may be translational biomarkers for schizophrenia (SZ). This study tests whether aSSR deviations are (i)specific to SZ across the psychosis dimension, (ii)specific to particular frequency bands, and (iii)present in bipolar I disorder without psychosis (BDNP). Methods: Beta (20-), low- (40-), and high-gamma (80-Hz)aSSRs were measured with EEG and compared across 113 SZ, 105 schizoaffective disorder (SAD), 99 bipolar disorder with psychosis (BDP), 68 BDNP, and 137 healthy comparison subjects (HC). Standard aSSR measures (single-trial power [STP]and inter-trial phase coherence [ITC]), as well as evoked responses to stimulus onsets/offsets and pre-stimulus power, were quantified. Multivariate canonical discriminant analysis was used to summarize variables that efficiently and maximally differentiated groups. Results: (i)Psychosis groups showed reduced responses on ITC 20 Hz, STP/ITC 40 Hz, STP/ITC 80 Hz, indicating dimensional reductions in aSSR across the psychosis spectrum not specific to aSSR frequency. For the 40- and 80-Hz ITCs there was greater reduction in SZ compared to SAD, possibly indexing cortical disruptions linked to psychosis without mood symptoms. (ii)All probands had elevated pre-stimulus power, possibly compromising neural entrainment to the steady-state stimuli. (iii)Onset/Offset and 80 Hz ITC responses were most important for group discrimination and showed dimensional reduction across the schizo-bipolar spectrum. Conclusions: Deviant aSSRs were found across the schizo-bipolar spectrum at multiple frequencies with psychosis status and severity linked to greatest reductions at low and high gamma.

KW - Auditory steady-state response

KW - Bipolar disorder

KW - EEG biomarkers

KW - Gamma oscillations

KW - Psychosis

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=85065229547&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065229547&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2019.04.014

DO - 10.1016/j.schres.2019.04.014

M3 - Article

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

ER -