(Chemical Equation Presented) Depending on the nature of the metal catalyst, ω-hydroxy propargylic acetates choose between alternative cycloetherification manifolds to produce functionalized heterocycles in high yields. AuCl catalyzes the formation of oxacyclic enol acetates, whereas [Cl2Pt(CH2CH2)]2 (Zeise's dimer) will induce a propargylic substitution via an unprecedented S N2′-type allenic substitution from within a chelated square planar cationic Pt(II) complex.
ASJC Scopus subject areas
- Organic Chemistry
- Physical and Theoretical Chemistry
- Molecular Medicine