Author Correction: CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells (Nature, (2017), 546, 7656, (168-172), 10.1038/nature22359)

Jiyeon Kim, Zeping Hu, Ling Cai, Kailong Li, Eunhee Choi, Brandon Faubert, Divya Bezwada, Jaime Rodriguez-Canales, Pamela Villalobos, Yu Fen Lin, Min Ni, Kenneth E. Huffman, Luc Girard, Lauren A. Byers, Keziban Unsal-Kacmaz, Christopher G. Peña, John V. Heymach, Els Wauters, Johan Vansteenkiste, Diego H CastrillonPing-chi B Chen, Ignacio Wistuba, Diether Lambrechts, Jian Xu, John D Minna, Ralph J DeBerardinis

Research output: Contribution to journalComment/debate

Abstract

Further analysis has revealed that the signal reported in Extended Data Fig. 1c of this Letter is attributed to phosphorylethanolamine, not carbamoyl phosphate. A newly developed derivatization method revealed that the level of carbamoyl phosphate in these NSCLC extracts is below the detection threshold of approximately 10 nanomoles. These findings do not alter the overall conclusions of the Letter; see associated Amendment for full details. The Letter has not been corrected online.

Original languageEnglish (US)
Pages (from-to)E4
JournalNature
Volume569
Issue number7756
DOIs
StatePublished - May 16 2019

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Carbamyl Phosphate
Lung Neoplasms
DNA
pyrimidine
phosphorylethanolamine

ASJC Scopus subject areas

  • General

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Author Correction : CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells (Nature, (2017), 546, 7656, (168-172), 10.1038/nature22359). / Kim, Jiyeon; Hu, Zeping; Cai, Ling; Li, Kailong; Choi, Eunhee; Faubert, Brandon; Bezwada, Divya; Rodriguez-Canales, Jaime; Villalobos, Pamela; Lin, Yu Fen; Ni, Min; Huffman, Kenneth E.; Girard, Luc; Byers, Lauren A.; Unsal-Kacmaz, Keziban; Peña, Christopher G.; Heymach, John V.; Wauters, Els; Vansteenkiste, Johan; Castrillon, Diego H; Chen, Ping-chi B; Wistuba, Ignacio; Lambrechts, Diether; Xu, Jian; Minna, John D; DeBerardinis, Ralph J.

In: Nature, Vol. 569, No. 7756, 16.05.2019, p. E4.

Research output: Contribution to journalComment/debate

Kim, J, Hu, Z, Cai, L, Li, K, Choi, E, Faubert, B, Bezwada, D, Rodriguez-Canales, J, Villalobos, P, Lin, YF, Ni, M, Huffman, KE, Girard, L, Byers, LA, Unsal-Kacmaz, K, Peña, CG, Heymach, JV, Wauters, E, Vansteenkiste, J, Castrillon, DH, Chen, PB, Wistuba, I, Lambrechts, D, Xu, J, Minna, JD & DeBerardinis, RJ 2019, 'Author Correction: CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells (Nature, (2017), 546, 7656, (168-172), 10.1038/nature22359)', Nature, vol. 569, no. 7756, pp. E4. https://doi.org/10.1038/s41586-019-1133-3
Kim, Jiyeon ; Hu, Zeping ; Cai, Ling ; Li, Kailong ; Choi, Eunhee ; Faubert, Brandon ; Bezwada, Divya ; Rodriguez-Canales, Jaime ; Villalobos, Pamela ; Lin, Yu Fen ; Ni, Min ; Huffman, Kenneth E. ; Girard, Luc ; Byers, Lauren A. ; Unsal-Kacmaz, Keziban ; Peña, Christopher G. ; Heymach, John V. ; Wauters, Els ; Vansteenkiste, Johan ; Castrillon, Diego H ; Chen, Ping-chi B ; Wistuba, Ignacio ; Lambrechts, Diether ; Xu, Jian ; Minna, John D ; DeBerardinis, Ralph J. / Author Correction : CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells (Nature, (2017), 546, 7656, (168-172), 10.1038/nature22359). In: Nature. 2019 ; Vol. 569, No. 7756. pp. E4.
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abstract = "Further analysis has revealed that the signal reported in Extended Data Fig. 1c of this Letter is attributed to phosphorylethanolamine, not carbamoyl phosphate. A newly developed derivatization method revealed that the level of carbamoyl phosphate in these NSCLC extracts is below the detection threshold of approximately 10 nanomoles. These findings do not alter the overall conclusions of the Letter; see associated Amendment for full details. The Letter has not been corrected online.",
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T2 - CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells (Nature, (2017), 546, 7656, (168-172), 10.1038/nature22359)

AU - Kim, Jiyeon

AU - Hu, Zeping

AU - Cai, Ling

AU - Li, Kailong

AU - Choi, Eunhee

AU - Faubert, Brandon

AU - Bezwada, Divya

AU - Rodriguez-Canales, Jaime

AU - Villalobos, Pamela

AU - Lin, Yu Fen

AU - Ni, Min

AU - Huffman, Kenneth E.

AU - Girard, Luc

AU - Byers, Lauren A.

AU - Unsal-Kacmaz, Keziban

AU - Peña, Christopher G.

AU - Heymach, John V.

AU - Wauters, Els

AU - Vansteenkiste, Johan

AU - Castrillon, Diego H

AU - Chen, Ping-chi B

AU - Wistuba, Ignacio

AU - Lambrechts, Diether

AU - Xu, Jian

AU - Minna, John D

AU - DeBerardinis, Ralph J

PY - 2019/5/16

Y1 - 2019/5/16

N2 - Further analysis has revealed that the signal reported in Extended Data Fig. 1c of this Letter is attributed to phosphorylethanolamine, not carbamoyl phosphate. A newly developed derivatization method revealed that the level of carbamoyl phosphate in these NSCLC extracts is below the detection threshold of approximately 10 nanomoles. These findings do not alter the overall conclusions of the Letter; see associated Amendment for full details. The Letter has not been corrected online.

AB - Further analysis has revealed that the signal reported in Extended Data Fig. 1c of this Letter is attributed to phosphorylethanolamine, not carbamoyl phosphate. A newly developed derivatization method revealed that the level of carbamoyl phosphate in these NSCLC extracts is below the detection threshold of approximately 10 nanomoles. These findings do not alter the overall conclusions of the Letter; see associated Amendment for full details. The Letter has not been corrected online.

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