Autoantikroppar som serologiska markörer i diagnostiken av glomerulonefrit.

Translated title of the contribution: Autoantibodies as serological markers in the diagnosis of glomerulonephritis

R. Saxena, C. Johansson, P. Bygren, J. Wieslander

Research output: Contribution to journalArticle

Abstract

Autoimmunity is now regarded as the unequivocally predominant pathogenic process underlying most forms of primary and secondary glomerulonephritis in humans, and a number of autoantibodies occurring in conjunction with glomerulonephritis have been discovered. However, apart from the anti-NC1 antibodies occurring in classic Goodpasture's syndrome, the exact pathogenic role of these autoantibodies in human glomerulonephritis remains to be established, though this in no way diminishes the importance of their study. They have been of enormous value in subclassifying glomerulonephritis, previously thought to be a homogeneous entity. Autoantibody analysis has become a vital aid in the early diagnosis of rapidly progressive glomerulonephritis, which in turn has enabled treatment to be started early, thus contributing to a decline in the morbidity and mortality resulting from these disorders. Moreover, investigation of these autoantibodies will be of immense value in future studies focused on the pathogenic mechanisms involved in glomerulonephritis.

Original languageUndefined
Pages (from-to)117-120
Number of pages4
JournalLakartidningen
Volume89
Issue number3
StatePublished - Jan 15 1992

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Glomerulonephritis
Autoantibodies
Anti-Glomerular Basement Membrane Disease
Autoimmunity
Early Diagnosis
Anti-Idiotypic Antibodies
Morbidity
Mortality

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Saxena, R., Johansson, C., Bygren, P., & Wieslander, J. (1992). Autoantikroppar som serologiska markörer i diagnostiken av glomerulonefrit. Lakartidningen, 89(3), 117-120.

Autoantikroppar som serologiska markörer i diagnostiken av glomerulonefrit. / Saxena, R.; Johansson, C.; Bygren, P.; Wieslander, J.

In: Lakartidningen, Vol. 89, No. 3, 15.01.1992, p. 117-120.

Research output: Contribution to journalArticle

Saxena, R, Johansson, C, Bygren, P & Wieslander, J 1992, 'Autoantikroppar som serologiska markörer i diagnostiken av glomerulonefrit.', Lakartidningen, vol. 89, no. 3, pp. 117-120.
Saxena R, Johansson C, Bygren P, Wieslander J. Autoantikroppar som serologiska markörer i diagnostiken av glomerulonefrit. Lakartidningen. 1992 Jan 15;89(3):117-120.
Saxena, R. ; Johansson, C. ; Bygren, P. ; Wieslander, J. / Autoantikroppar som serologiska markörer i diagnostiken av glomerulonefrit. In: Lakartidningen. 1992 ; Vol. 89, No. 3. pp. 117-120.
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