Autoantibodies to the δ-opioid receptor function as opioid agonists and display immunomodulatory activity

Parvathi Ranganathan, Hao Chen, Miranda K. Adelman, Samuel F. Schluter

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

In this report, we show that affinity purified human anti-delta opioid receptor (DOR) autoantibodies from IVIG are specific to DOR and possess agonistic properties displayed by their ability to dramatically decrease forskolin stimulated cAMP accumulation. Anti-DOR autoantibody also caused phosphorylation of the opioid receptor. Anti-DOR autoantibody treatment showed a significant reduction in CXCR4 gene expression as well as surface protein expression. In contrast, anti-DOR autoantibody treatment significantly upregulated CCR5 gene and protein expression. The presence of anti-DOR autoantibodies in IVIG and their potent immunomodulatory activity is further evidence to support the cross-talk between the neuroendocrine and immune systems.

Original languageEnglish (US)
Pages (from-to)65-73
Number of pages9
JournalJournal of Neuroimmunology
Volume217
Issue number1-2
DOIs
StatePublished - Dec 10 2009
Externally publishedYes

Keywords

  • Autoantibodies
  • Immunomodulation
  • Opioid receptors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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