Autografting for multiple myeloma: A 5-year experience at a single institution

P. Mahendra, I. M. Hood, D. Johnson, M. Ethell, H. K. Jestice, M. A. Scott, P. Barker, G. Bass, T. P. Baglin, R. E. Marcus

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Over a 5-year period, we have performed 33 autologous bone marrow or PBPC transplantations for multiple myeloma. Nine patients were in complete remission and 24 in partial remission at time of transplantation. Conditioning regimens were BEM (BCNU, etoposide and melphalan) in 29, busulphan and cyclophosphamide in three and melphalan alone in one. Two patients (6%), died within 3 months of transplant-related mortality, seven (21.3%), died of disease progression at a median follow-up of 11 months (range 4-24). Twenty-four patients (72.7%) are alive at a median follow-up of 15 months (range 4-61). Of nine patients transplanted in CR, four have relapsed and are alive and five remain in CR. Of 24 patients transplanted in PR, nine have died, six remain in PR, eight achieved CR and one has progressive disease. The overall median progression-free survival (PFS) is 31 months (95% CI = 20-42). For patients transplanted in PR the median PFS is 24 months (95% CI = 22-26), the median PFS for patients transplanted in CR has not yet been reached. The median PFS for patients achieving CR pre- or post-transplantation was better than for patients neither achieving CR pre- nor post-transplantation (P = 0.05). The median PFS was also significantly improved for patients requiring only primary therapy, compared to patients needing second-line therapy to achieve CR or stable PR prior to transplantation (31 vs 11 months, P = 0.02).

Original languageEnglish (US)
Pages (from-to)759-763
Number of pages5
JournalBone Marrow Transplantation
Volume16
Issue number6
StatePublished - Dec 1 1995

Keywords

  • Autografting
  • Multiple myeloma

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Mahendra, P., Hood, I. M., Johnson, D., Ethell, M., Jestice, H. K., Scott, M. A., Barker, P., Bass, G., Baglin, T. P., & Marcus, R. E. (1995). Autografting for multiple myeloma: A 5-year experience at a single institution. Bone Marrow Transplantation, 16(6), 759-763.