Autoimmune autonomic ganglionopathy with Sjögren's syndrome: Significance of ganglionic acetylcholine receptor antibody and therapeutic approach

Takayuki Kondo, Haruhisa Inoue, Takashi Usui, Tsuneyo Mimori, Hidekazu Tomimoto, Steven Vernino, Ryosuke Takahashi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Autoimmune autonomic ganglionopathy (AAG) is a disorder defined by antibodies to the nicotinic acetylcholine receptor of the autonomic ganglia. We report two patients with chronically progressing dysautonomia with Sjögren's syndrome (SS). The first case showed elevated titer of ganglionic acetylcholine receptor (AChR) antibody and improved with oral intake of prednisolone. In contrast, the second case showed no elevation of ganglionic AChR antibody titer and had poor response to immunomodulatory therapy. These two cases indicate that chronic AAG may be treatable by immunomodulatory therapy, and have relevance to SS.

Original languageEnglish (US)
Pages (from-to)33-35
Number of pages3
JournalAutonomic Neuroscience: Basic and Clinical
Volume146
Issue number1-2
DOIs
StatePublished - Mar 12 2009

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Cholinergic Receptors
Immunomodulation
Antibodies
Autonomic Ganglia
Primary Dysautonomias
Nicotinic Receptors
Prednisolone
Therapeutics

Keywords

  • Autoimmune autonomic ganglionopathy
  • Ganglionic acetylcholine receptor antibody
  • Prednisolone
  • Sjögren's syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Autoimmune autonomic ganglionopathy with Sjögren's syndrome : Significance of ganglionic acetylcholine receptor antibody and therapeutic approach. / Kondo, Takayuki; Inoue, Haruhisa; Usui, Takashi; Mimori, Tsuneyo; Tomimoto, Hidekazu; Vernino, Steven; Takahashi, Ryosuke.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 146, No. 1-2, 12.03.2009, p. 33-35.

Research output: Contribution to journalArticle

Kondo, Takayuki ; Inoue, Haruhisa ; Usui, Takashi ; Mimori, Tsuneyo ; Tomimoto, Hidekazu ; Vernino, Steven ; Takahashi, Ryosuke. / Autoimmune autonomic ganglionopathy with Sjögren's syndrome : Significance of ganglionic acetylcholine receptor antibody and therapeutic approach. In: Autonomic Neuroscience: Basic and Clinical. 2009 ; Vol. 146, No. 1-2. pp. 33-35.
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