Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy

Susana L. Silva, Adriana Albuquerque, Andreia J. Amaral, Quan Zhen Li, Catarina Mota, Rémi Cheynier, Rui M.M. Victorino, M. Conceição Pereira-Santos, Ana E. Sousa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The contribution of the decline in thymic activity for the emergence of autoimmunity is still debatable. Immune-competent adults submitted to complete thymectomy early in life provide a unique model to address this question. We applied here strict criteria to identify adults lacking thymic activity based on sjTREC levels, to exclude thymic rebound and/or ectopic thymuses. In agreement, they featured severe naïve CD4 T-cell depletion and contraction of T-cell receptor diversity. Notwithstanding this, there was neither increased incidence of autoimmune disease in comparison with age-matched controls nor significant changes in their IgG/IgA/IgM/IgE autoreactivity profiles, as assessed through extensive arrays. We reasoned that the observed relative preservation of the regulatory T-cell compartment, including maintenance of naïve regulatory CD4 T-cells, may contribute to limit the emergence of autoimmunity upon thymectomy. Our findings have implications in other clinical settings with impaired thymic activity, and are particularly relevant to studies of autoimmunity in ageing.

Original languageEnglish (US)
Article numbere0180385
JournalPLoS One
Volume12
Issue number7
DOIs
StatePublished - Jul 1 2017

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Allergies
Thymectomy
autoimmunity
T-cells
infancy
Autoimmunity
hypersensitivity
Hypersensitivity
T-lymphocytes
Regulatory T-Lymphocytes
Thymus
T-Cell Antigen Receptor
Immunoglobulin A
Thymus Gland
Immunoglobulin E
Autoimmune Diseases
Immunoglobulin M
autoimmune diseases
Immunoglobulin G
Aging of materials

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Silva, S. L., Albuquerque, A., Amaral, A. J., Li, Q. Z., Mota, C., Cheynier, R., ... Sousa, A. E. (2017). Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy. PLoS One, 12(7), [e0180385]. https://doi.org/10.1371/journal.pone.0180385

Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy. / Silva, Susana L.; Albuquerque, Adriana; Amaral, Andreia J.; Li, Quan Zhen; Mota, Catarina; Cheynier, Rémi; Victorino, Rui M.M.; Pereira-Santos, M. Conceição; Sousa, Ana E.

In: PLoS One, Vol. 12, No. 7, e0180385, 01.07.2017.

Research output: Contribution to journalArticle

Silva, SL, Albuquerque, A, Amaral, AJ, Li, QZ, Mota, C, Cheynier, R, Victorino, RMM, Pereira-Santos, MC & Sousa, AE 2017, 'Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy', PLoS One, vol. 12, no. 7, e0180385. https://doi.org/10.1371/journal.pone.0180385
Silva, Susana L. ; Albuquerque, Adriana ; Amaral, Andreia J. ; Li, Quan Zhen ; Mota, Catarina ; Cheynier, Rémi ; Victorino, Rui M.M. ; Pereira-Santos, M. Conceição ; Sousa, Ana E. / Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy. In: PLoS One. 2017 ; Vol. 12, No. 7.
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