Autoimmunity and glomerulonephritis

Ramesh Saxena, Charlott Johansson, Per Bygren, Jörgen Wieslander

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Autoimmunity is now unequivocally regarded as the predominant pathogenic process underlying most forms of primary and secondary glomerulonephritis in humans. Most of the investigations so far have been focused upon humoral mechanisms. Consequently, the role of cell-mediated immunity in nephritis is still incompletely understood. Nonetheless, as a result of contemporary studies, a number of previously unidentified auto-antibodies in association with glomerulonephritis have been discovered. However, apart from anti-NC1 antibodies in the classical Goodpasture syndrome, the exact role of these auto-antibodies in the pathogenesis of glomerulonephritis yet remains undefined. This fact, however, does not undermine the relevance of exploring these auto-antibodies. They have been of immense help in sub-classifying glomerulonephritis previously thought homogeneous (Figure 3). Besides, analysis of autoantibodies has assisted tremendously in the early diagnosis of rapidly progressive glomerulonephritis. This, in turn, has aided in early commencement of therapy thus contributing to regression in morbidity and mortality resulting from these disorders. Moreover, investigation of these autoantibodies is of enormous value for future studies aimed at understanding the pathogenic mechanisms involved in glomerulonephritis.

Original languageEnglish (US)
Pages (from-to)242-250
Number of pages9
JournalPostgraduate Medical Journal
Volume68
Issue number798
DOIs
StatePublished - 1992

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Glomerulonephritis
Autoimmunity
Autoantibodies
Antibodies
Anti-Glomerular Basement Membrane Disease
Nephritis
Secondary Prevention
Cellular Immunity
Early Diagnosis
Anti-Idiotypic Antibodies
Morbidity
Mortality

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Epidemiology
  • Medicine(all)

Cite this

Saxena, R., Johansson, C., Bygren, P., & Wieslander, J. (1992). Autoimmunity and glomerulonephritis. Postgraduate Medical Journal, 68(798), 242-250. https://doi.org/10.1136/pgmj.68.798.242

Autoimmunity and glomerulonephritis. / Saxena, Ramesh; Johansson, Charlott; Bygren, Per; Wieslander, Jörgen.

In: Postgraduate Medical Journal, Vol. 68, No. 798, 1992, p. 242-250.

Research output: Contribution to journalArticle

Saxena, R, Johansson, C, Bygren, P & Wieslander, J 1992, 'Autoimmunity and glomerulonephritis', Postgraduate Medical Journal, vol. 68, no. 798, pp. 242-250. https://doi.org/10.1136/pgmj.68.798.242
Saxena, Ramesh ; Johansson, Charlott ; Bygren, Per ; Wieslander, Jörgen. / Autoimmunity and glomerulonephritis. In: Postgraduate Medical Journal. 1992 ; Vol. 68, No. 798. pp. 242-250.
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