Autoimmunity-associated autonomic failure with sympathetic denervation

David S. Goldstein, Courtney Holmes, Patti Sullivan, Vincenzo Donadio, Risa Isonaka, Elizabeth Zhong, Bobby Pourier, Steven Vernino, Irwin J. Kopin, Yehonatan Sharabi

Research output: Contribution to journalArticle

8 Scopus citations


We report a case of autoimmunity-associated autonomic failure in a young adult woman who developed arthritis followed 3 years later by pandysautonomia. There was early recovery of parasympathetic functions but persistent neurogenic orthostatic hypotension from post-ganglionic sympathetic denervation. Clinical laboratory testing indicated variable amounts of sympathetic neuronal re-sprouting in the heart, kidneys, eyes, and body as a whole upon follow-up evaluation after 1.5 years.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalClinical Autonomic Research
StateAccepted/In press - Nov 12 2016


  • Autoimmunity
  • Autonomic failure
  • Catecholamine
  • Norepinephrine
  • Sympathetic

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology

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  • Cite this

    Goldstein, D. S., Holmes, C., Sullivan, P., Donadio, V., Isonaka, R., Zhong, E., Pourier, B., Vernino, S., Kopin, I. J., & Sharabi, Y. (Accepted/In press). Autoimmunity-associated autonomic failure with sympathetic denervation. Clinical Autonomic Research, 1-6.