Automatic Registration and Fusion of High Resolution Micro-CT and Lung Perfusion SPECT Images of the Rat

Baowei Fei, Christian Wietholt, Anne V. Clough, Christopher A. Dawson, David L. Wilson

Research output: Contribution to journalConference article


Small animal imaging can provide high-throughput phenotypic data for functional genomic studies and better mechanistic understanding of disease. Fusion of anatomical and functional images will aid interpretation of functional images having relatively little anatomical detail. In this study, we are investigating automatic registration and fusion visualization methods for micro-CT and SPECT images of rat lung. The immediate application is studies of pulmonary perfusion in a healthy rat and one with an occluded left pulmonary artery. Registration experiments were performed on images acquired from rats and a phantom. Fusion visualization showed excellent registration results. Quantitative measures such as distances and perimeters from phantom results show that the registration is quite accurate.

Original languageEnglish (US)
Pages (from-to)592-594
Number of pages3
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Publication statusPublished - Dec 1 2003
Externally publishedYes
EventA New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico
Duration: Sep 17 2003Sep 21 2003



  • Image registration and fusion
  • Lung perfusion
  • Micro-CT
  • Small animal imaging

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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