TY - JOUR
T1 - Autonomic and inflammatory consequences of posttraumatic stress disorder and the link to cardiovascular disease
AU - Brudey, Chevelle
AU - Park, Jeanie
AU - Wiaderkiewicz, Jan
AU - Kobayashi, Ihori
AU - Mellman, Thomas
AU - Marvar, Paul J.
N1 - Publisher Copyright:
© 2015 the American Physiological Society.
PY - 2015/8/18
Y1 - 2015/8/18
N2 - Stress and anxiety-related disorders are on the rise in both military and general populations. Over the next decade, it is predicted that treatment of these conditions, in particular, posttraumatic stress disorder (PTSD), along with its associated longterm comorbidities, will challenge the health care system. Multiple organ systems are adversely affected by PTSD, and PTSD is linked to cancer, arthritis, digestive disease, and cardiovascular disease. Evidence for a strong link between PTSD and cardiovascular disease is compelling, and this review describes current clinical data linking PTSD to cardiovascular disease, via inflammation, autonomic dysfunction, and the renin-angiotensin system. Recent clinical and preclinical evidence regarding the role of the renin-angiotensin system in the extinction of fear memory and relevance in PTSD-related immune and autonomic dysfunction is also addressed.
AB - Stress and anxiety-related disorders are on the rise in both military and general populations. Over the next decade, it is predicted that treatment of these conditions, in particular, posttraumatic stress disorder (PTSD), along with its associated longterm comorbidities, will challenge the health care system. Multiple organ systems are adversely affected by PTSD, and PTSD is linked to cancer, arthritis, digestive disease, and cardiovascular disease. Evidence for a strong link between PTSD and cardiovascular disease is compelling, and this review describes current clinical data linking PTSD to cardiovascular disease, via inflammation, autonomic dysfunction, and the renin-angiotensin system. Recent clinical and preclinical evidence regarding the role of the renin-angiotensin system in the extinction of fear memory and relevance in PTSD-related immune and autonomic dysfunction is also addressed.
KW - Cardiovascular disease
KW - Posttraumatic stress disorder
KW - Renin-angiotensin system
UR - http://www.scopus.com/inward/record.url?scp=84939520886&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939520886&partnerID=8YFLogxK
U2 - 10.1152/ajpregu.00343.2014
DO - 10.1152/ajpregu.00343.2014
M3 - Article
C2 - 26062635
AN - SCOPUS:84939520886
SN - 0363-6119
VL - 309
SP - R315-R321
JO - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
JF - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
IS - 4
ER -