Autonomic circulatory control during pregnancy in humans

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Pregnancy is associated with dramatic alterations in maternal hemodynamics, which begin as early as 4 to 5 weeks of gestation. It has been proposed that these changes occur through autonomic control mechanisms, but the actual role of the autonomic nervous system in pregnancy is poorly understood. Here, we review what is known about the hemodynamic adaptation, changes in vascular endothelial function, sympathetic neural control and vascular responsiveness in pregnancy, and baroreflex function during pregnancy in humans. However, whether and how the sympathetic nervous system plays a role in hemodynamic homeostasis during early human pregnancy remains completely unknown. Understanding the pathophysiology underlying autonomic control of maternal hemodynamics may be particularly important for prevention of cardiovascular complications during pregnancy and may improve risk stratification and prevention of cardiovascular disease for women well beyond the postpartum period.

Original languageEnglish (US)
Pages (from-to)330-337
Number of pages8
JournalSeminars in Reproductive Medicine
Volume27
Issue number4
DOIs
StatePublished - Jul 2009

Fingerprint

Pregnancy
Hemodynamics
Cardiovascular Pregnancy Complications
Blood Vessels
Mothers
Baroreflex
Autonomic Nervous System
Sympathetic Nervous System
Postpartum Period
Homeostasis
Cardiovascular Diseases

Keywords

  • Arterial pressure
  • Baroreflexes
  • Pregnancy
  • Vasomotor sympathetic activity

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Autonomic circulatory control during pregnancy in humans. / Fu, Qi; Levine, Benjamin D.

In: Seminars in Reproductive Medicine, Vol. 27, No. 4, 07.2009, p. 330-337.

Research output: Contribution to journalArticle

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