Autonomic dysfunction in multiple sclerosis: Implications for exercise

Mu Huang, Ollie Jay, Scott L. Davis

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Multiple sclerosis (MS), a progressive neurological disease, can result in autonomic dysfunction. Impairments in the autonomic control of cardiovascular and thermoregulatory function during exercise have been observed in MS. Attenuated elevations in blood pressure during exercise in MS patients can negatively impact blood flow to skeletal muscle. Diminished sweating during exercise may impair heat dissipation likely limiting the exercise intensity that can be performed before detrimental core temperatures are reached. Further understanding the physiologic mechanisms of autonomic dysfunction during exercise in MS may lead to the development of novel therapeutic strategies targeted at improving quality of life in individuals with this disease.

Original languageEnglish (US)
Pages (from-to)82-85
Number of pages4
JournalAutonomic Neuroscience: Basic and Clinical
Volume188
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Multiple Sclerosis
Exercise
Sweating
Skeletal Muscle
Hot Temperature
Quality of Life
Blood Pressure
Temperature
Therapeutics

Keywords

  • Blood pressure
  • Cardiovascular
  • Demyelination
  • Sweat
  • Sympathetic nerve activity
  • Thermoregulation

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Autonomic dysfunction in multiple sclerosis : Implications for exercise. / Huang, Mu; Jay, Ollie; Davis, Scott L.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 188, 01.01.2015, p. 82-85.

Research output: Contribution to journalReview article

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