Autonomic dysfunction in peripheral nerve disease

Phillip A. Low, Steven Vernino, Guillermo Suarez

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Autonomic neuropathies are inherited or acquired neuropathies in which autonomic nerve fibers are selectively or disproportionately affected. Generally, sympathetic and parasympathetic fibers are both affected but there are exceptions. Acquired cases can be autoimmune; due to diabetes, amyloidosis, drugs, or toxins; or idiopathic. Autoimmune autonomic neuropathy is often subacute, sometimes associated with a neo-plasm, and associated with high titers of antibody to ganglionic nicotinic acetylcholine receptor in about half of the severe cases. The molecular basis of inherited autonomic neuropathies is better known, including recent identification of the loci and genes of hereditary sensory and autonomic neuropathies types I, III, and IV. The inherited amyloid neuropathies are due to mutations of three proteins: transthyretin, apolipoprotein A1, and gelsolin. Non-invasive autonomic testing complements clinical and electrophysiological characterization of the autonomic neuropathies.

Original languageEnglish (US)
Pages (from-to)646-661
Number of pages16
JournalMuscle and Nerve
Volume27
Issue number6
DOIs
StatePublished - Jun 1 2003

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Hereditary Sensory and Autonomic Neuropathies
Peripheral Nervous System Diseases
Amyloid Neuropathies
Familial Dysautonomia
Gelsolin
Adrenergic Fibers
Autonomic Pathways
Prealbumin
Apolipoprotein A-I
Nicotinic Receptors
Amyloidosis
Nerve Fibers
Mutation
Antibodies
Pharmaceutical Preparations
Genes
Proteins

Keywords

  • Autoimmune autonomic neuropathy
  • Autonomic
  • Ganglionic antibody
  • Paraneoplastic
  • Thermoregulatory sweat test

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Autonomic dysfunction in peripheral nerve disease. / Low, Phillip A.; Vernino, Steven; Suarez, Guillermo.

In: Muscle and Nerve, Vol. 27, No. 6, 01.06.2003, p. 646-661.

Research output: Contribution to journalArticle

Low, Phillip A. ; Vernino, Steven ; Suarez, Guillermo. / Autonomic dysfunction in peripheral nerve disease. In: Muscle and Nerve. 2003 ; Vol. 27, No. 6. pp. 646-661.
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