Autonomic neural control of dynamic cerebral autoregulation in humans

Rong Zhang, Julie H. Zuckerman, Kenichi Iwasaki, Thad E. Wilson, Craig G. Crandall, Benjamin D. Levine

Research output: Contribution to journalArticle

299 Citations (Scopus)

Abstract

Background - The purpose of the present study was to determine the role of autonomic neural control of dynamic cerebral autoregulation in humans. Methods and Results - We measured arterial pressure and cerebral blood flow (CBF) velocity in 12 healthy subjects (aged 29±6 years) before and after ganglion blockade with trimethaphan. CBF velocity was measured in the middle cerebral artery using transcranial Doppler. The magnitude of spontaneous changes in mean blood pressure and CBF velocity were quantified by spectral analysis. The transfer function gain, phase, and coherence between these variables were estimated to quantify dynamic cerebral autoregulation. After ganglion blockade, systolic and pulse pressure decreased significantly by 13% and 26%, respectively. CBF velocity decreased by 6% (P<0.05). In the very low frequency range (0.02 to 0.07 Hz), mean blood pressure variability decreased significantly (by 82%), while CBF velocity variability persisted. Thus, transfer function gain increased by 81%. In addition, the phase lead of CBF velocity to arterial pressure diminished. These changes in transfer function gain and phase persisted despite restoration of arterial pressure by infusion of phenylephrine and normalization of mean blood pressure variability by oscillatory lower body negative pressure. Conclusions - These data suggest that dynamic cerebral autoregulation is altered by ganglion blockade. We speculate that autonomic neural control of the cerebral circulation is tonically active and likely plays a significant role in the regulation of beat-to-beat CBF in humans.

Original languageEnglish (US)
Pages (from-to)1814-1820
Number of pages7
JournalCirculation
Volume106
Issue number14
DOIs
StatePublished - Oct 1 2002

Fingerprint

Cerebrovascular Circulation
Blood Flow Velocity
Homeostasis
Blood Pressure
Ganglia
Arterial Pressure
Trimethaphan
Lower Body Negative Pressure
Middle Cerebral Artery
Phenylephrine
Healthy Volunteers

Keywords

  • Blood flow
  • Brain
  • Nervous system, autonomic
  • Ultrasonics

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Autonomic neural control of dynamic cerebral autoregulation in humans. / Zhang, Rong; Zuckerman, Julie H.; Iwasaki, Kenichi; Wilson, Thad E.; Crandall, Craig G.; Levine, Benjamin D.

In: Circulation, Vol. 106, No. 14, 01.10.2002, p. 1814-1820.

Research output: Contribution to journalArticle

Zhang, Rong ; Zuckerman, Julie H. ; Iwasaki, Kenichi ; Wilson, Thad E. ; Crandall, Craig G. ; Levine, Benjamin D. / Autonomic neural control of dynamic cerebral autoregulation in humans. In: Circulation. 2002 ; Vol. 106, No. 14. pp. 1814-1820.
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