Autonomic regulation of blood pressure in menopause

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

A large body of evidence indicates a major influence of sex hormones, particularly estrogen, on autonomic regulation of blood pressure (BP). The sympathetic nervous system is now widely recognized as a major regulator of BP homeostasis and contributor to pathogenesis of hypertension in humans. Menopause is accompanied by an accelerated agerelated rise in sympathetic nerve activity (SNA). Mechanisms underlying sympathetic activation in menopause are unknown but may be related to impaired central modulation of baroreflex function or direct inhibitory influence of estrogen on SNA. Menopause is also accompanied by enhanced a-adrenergic peripheral vasoconstriction both at rest and during exercise. In ovariectomized rats, reduced nitric oxide release from the skeletal muscle caused by estrogen deficiency contributes to augmented sympathetic vasoconstriction during muscle contraction. The alteration in central autonomic regulation coupled with enhanced vascular adrenergic sensitivity may be responsible for elevation in resting BP and exaggerated pressor responses to exercise and mental stress in postmenopausal women.

Original languageEnglish (US)
Pages (from-to)338-345
Number of pages8
JournalSeminars in Reproductive Medicine
Volume27
Issue number4
DOIs
StatePublished - Jul 2009

Fingerprint

Menopause
Estrogens
Blood Pressure
Vasoconstriction
Adrenergic Agents
Exercise
Baroreflex
Sympathetic Nervous System
Gonadal Steroid Hormones
Muscle Contraction
Blood Vessels
Nitric Oxide
Skeletal Muscle
Homeostasis
Hypertension

Keywords

  • Hypertension
  • Menopause
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Autonomic regulation of blood pressure in menopause. / Vongpatanasin, Wanpen.

In: Seminars in Reproductive Medicine, Vol. 27, No. 4, 07.2009, p. 338-345.

Research output: Contribution to journalArticle

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