Autophagy and cancer metabolism

Juliet Goldsmith, Beth Levine, Jayanta Debnath

Research output: Chapter in Book/Report/Conference proceedingChapter

44 Citations (Scopus)

Abstract

The metabolism of malignant cells is profoundly altered in order to maintain their survival and proliferation in adverse microenvironmental conditions. Autophagy is an intracellular recycling process that maintains basal levels of metabolites and biosynthetic intermediates under starvation or other forms of stress, hence serving as an important mechanism for metabolic adaptation in cancer cells. Although it is widely acknowledged that autophagy sustains metabolism in neoplastic cells under duress, many questions remain with regard to the mutual relationship between autophagy and metabolism in cancer. Importantly, autophagy has often been described as a "double-edged sword" that can either impede or promote cancer initiation and progression. Here, we overview such a dual function of autophagy in tumorigenesis and our current understanding of the coordinated regulation of autophagy and cancer cell metabolism in the control of tumor growth, progression, and resistance to therapy.

Original languageEnglish (US)
Title of host publicationMethods in Enzymology
PublisherAcademic Press Inc.
Pages25-57
Number of pages33
Volume542
ISBN (Print)9780124166189
DOIs
StatePublished - 2014

Publication series

NameMethods in Enzymology
Volume542
ISSN (Print)00766879
ISSN (Electronic)15577988

Fingerprint

Autophagy
Metabolism
Neoplasms
Cells
Metabolites
Recycling
Tumors
Starvation
Carcinogenesis
Growth

Keywords

  • Autophagy
  • Cancer metabolism
  • Cancer therapy
  • Glutaminolysis
  • Glycolysis
  • Hypoxia

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Goldsmith, J., Levine, B., & Debnath, J. (2014). Autophagy and cancer metabolism. In Methods in Enzymology (Vol. 542, pp. 25-57). (Methods in Enzymology; Vol. 542). Academic Press Inc.. https://doi.org/10.1016/B978-0-12-416618-9.00002-9

Autophagy and cancer metabolism. / Goldsmith, Juliet; Levine, Beth; Debnath, Jayanta.

Methods in Enzymology. Vol. 542 Academic Press Inc., 2014. p. 25-57 (Methods in Enzymology; Vol. 542).

Research output: Chapter in Book/Report/Conference proceedingChapter

Goldsmith, J, Levine, B & Debnath, J 2014, Autophagy and cancer metabolism. in Methods in Enzymology. vol. 542, Methods in Enzymology, vol. 542, Academic Press Inc., pp. 25-57. https://doi.org/10.1016/B978-0-12-416618-9.00002-9
Goldsmith J, Levine B, Debnath J. Autophagy and cancer metabolism. In Methods in Enzymology. Vol. 542. Academic Press Inc. 2014. p. 25-57. (Methods in Enzymology). https://doi.org/10.1016/B978-0-12-416618-9.00002-9
Goldsmith, Juliet ; Levine, Beth ; Debnath, Jayanta. / Autophagy and cancer metabolism. Methods in Enzymology. Vol. 542 Academic Press Inc., 2014. pp. 25-57 (Methods in Enzymology).
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