Autophagy and epigenetics

Xu Dong Wang, Thomas G Gillette, Zhao V. Wang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Despite tremendous advances in diagnosis and treatment, cardiovascular disease remains the leading cause of mortality and morbidity worldwide. Accumulating evidence suggests that epigenetic regulation including DNA methylation, histone modification, and microRNA alteration may play an important role in cardiovascular disease. As a postmitotic cell, cardiac myocytes must rely on comprehensive protein quality control mechanisms to maintain cellular function and homeostasis. Autophagy, an evolutionarily conserved catabolic pathway responsible for degradation of long-lived proteins and defective organelles, is one such quality control mechanism and has been proposed as a therapeutic target for cardiovascular disease. Recent studies have demonstrated that alteration of epigenetic pathways can modify autophagic activity and impact cardiac function and cardiac myocyte survival. Here, we summarize the current knowledge regarding the functions of autophagy and epigenetics in cardiovascular disease.

Original languageEnglish (US)
Title of host publicationAutophagy and Cardiometabolic Diseases
Subtitle of host publicationFrom Molecular Mechanisms to Translational Medicine
PublisherElsevier
Pages295-303
Number of pages9
ISBN (Electronic)9780128052532
ISBN (Print)9780128054420
DOIs
StatePublished - Jan 1 2018

Keywords

  • Autophagy
  • Cardiomyopathy
  • Epigenetic regulation
  • Heart failure
  • Hypertensive heart disease

ASJC Scopus subject areas

  • Medicine(all)

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