Autophagy and Ferroptosis—What Is the Connection?

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Purpose of Review: Autophagy is a conserved intracellular degradation system and plays a dual role in cell death, depending on context and phase. Ferroptosis is a new form of regulated cell death that mainly depends on iron accumulation and lipid peroxidation. In this review, we summarize the processes of autophagy and ferroptosis and discuss their crosstalk mechanisms at the molecular level. Recent Findings: The original study shows that ferroptosis is morphologically, biochemically, and genetically distinct from autophagy and other types of cell death. However, recent studies demonstrate that activation of ferroptosis is indeed dependent on the induction of autophagy. Additionally, many ferroptosis regulators such as SLC7A11, GPX4, NRF2, p53, HSPB1, CISD1, FANCD2, and ACSL4 have been identified as potential regulators of autophagy. Summary: This review not only highlights the importance of autophagy as an emerging mechanism of ferroptosis but also raises new insights regarding regulated cell death.

Original languageEnglish (US)
Pages (from-to)153-159
Number of pages7
JournalCurrent Pathobiology Reports
Volume5
Issue number2
DOIs
StatePublished - Jun 1 2017
Externally publishedYes

Fingerprint

Autophagy
Cell Death
Lipid Peroxidation
Iron

Keywords

  • Autophagy
  • Ferroptosis
  • Iron metabolism
  • Lipid peroxidation
  • Molecular interaction
  • Signal transduction

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology
  • Cancer Research

Cite this

Autophagy and Ferroptosis—What Is the Connection? / Kang, Rui; Tang, Daolin.

In: Current Pathobiology Reports, Vol. 5, No. 2, 01.06.2017, p. 153-159.

Research output: Contribution to journalReview article

@article{d5c3838f47674160b9479c3f10174515,
title = "Autophagy and Ferroptosis—What Is the Connection?",
abstract = "Purpose of Review: Autophagy is a conserved intracellular degradation system and plays a dual role in cell death, depending on context and phase. Ferroptosis is a new form of regulated cell death that mainly depends on iron accumulation and lipid peroxidation. In this review, we summarize the processes of autophagy and ferroptosis and discuss their crosstalk mechanisms at the molecular level. Recent Findings: The original study shows that ferroptosis is morphologically, biochemically, and genetically distinct from autophagy and other types of cell death. However, recent studies demonstrate that activation of ferroptosis is indeed dependent on the induction of autophagy. Additionally, many ferroptosis regulators such as SLC7A11, GPX4, NRF2, p53, HSPB1, CISD1, FANCD2, and ACSL4 have been identified as potential regulators of autophagy. Summary: This review not only highlights the importance of autophagy as an emerging mechanism of ferroptosis but also raises new insights regarding regulated cell death.",
keywords = "Autophagy, Ferroptosis, Iron metabolism, Lipid peroxidation, Molecular interaction, Signal transduction",
author = "Rui Kang and Daolin Tang",
year = "2017",
month = "6",
day = "1",
doi = "10.1007/s40139-017-0139-5",
language = "English (US)",
volume = "5",
pages = "153--159",
journal = "Current Pathobiology Reports",
issn = "2167-485X",
publisher = "Springer US",
number = "2",

}

TY - JOUR

T1 - Autophagy and Ferroptosis—What Is the Connection?

AU - Kang, Rui

AU - Tang, Daolin

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Purpose of Review: Autophagy is a conserved intracellular degradation system and plays a dual role in cell death, depending on context and phase. Ferroptosis is a new form of regulated cell death that mainly depends on iron accumulation and lipid peroxidation. In this review, we summarize the processes of autophagy and ferroptosis and discuss their crosstalk mechanisms at the molecular level. Recent Findings: The original study shows that ferroptosis is morphologically, biochemically, and genetically distinct from autophagy and other types of cell death. However, recent studies demonstrate that activation of ferroptosis is indeed dependent on the induction of autophagy. Additionally, many ferroptosis regulators such as SLC7A11, GPX4, NRF2, p53, HSPB1, CISD1, FANCD2, and ACSL4 have been identified as potential regulators of autophagy. Summary: This review not only highlights the importance of autophagy as an emerging mechanism of ferroptosis but also raises new insights regarding regulated cell death.

AB - Purpose of Review: Autophagy is a conserved intracellular degradation system and plays a dual role in cell death, depending on context and phase. Ferroptosis is a new form of regulated cell death that mainly depends on iron accumulation and lipid peroxidation. In this review, we summarize the processes of autophagy and ferroptosis and discuss their crosstalk mechanisms at the molecular level. Recent Findings: The original study shows that ferroptosis is morphologically, biochemically, and genetically distinct from autophagy and other types of cell death. However, recent studies demonstrate that activation of ferroptosis is indeed dependent on the induction of autophagy. Additionally, many ferroptosis regulators such as SLC7A11, GPX4, NRF2, p53, HSPB1, CISD1, FANCD2, and ACSL4 have been identified as potential regulators of autophagy. Summary: This review not only highlights the importance of autophagy as an emerging mechanism of ferroptosis but also raises new insights regarding regulated cell death.

KW - Autophagy

KW - Ferroptosis

KW - Iron metabolism

KW - Lipid peroxidation

KW - Molecular interaction

KW - Signal transduction

UR - http://www.scopus.com/inward/record.url?scp=85045085246&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045085246&partnerID=8YFLogxK

U2 - 10.1007/s40139-017-0139-5

DO - 10.1007/s40139-017-0139-5

M3 - Review article

C2 - 29038744

AN - SCOPUS:85045085246

VL - 5

SP - 153

EP - 159

JO - Current Pathobiology Reports

JF - Current Pathobiology Reports

SN - 2167-485X

IS - 2

ER -