Abstract
Autophagy is a conserved catabolic stress response pathway that is increasingly recognized as an important component of both innate and acquired immunity to pathogens. The activation of autophagy during infection not only provides cell-autonomous protection through lysosomal degradation of invading pathogens (xenophagy), but also regulates signaling by other innate immune pathways. This review will focus on recent advances in our understanding of three major areas of the interrelationship between autophagy and innate immunity, including how autophagy is triggered during infection, how invading pathogens are targeted to autophagosomes, and how the autophagy pathway participates in " tuning" the innate immune response.
Original language | English (US) |
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Pages (from-to) | 699-711 |
Number of pages | 13 |
Journal | Seminars in Cell and Developmental Biology |
Volume | 21 |
Issue number | 7 |
DOIs | |
State | Published - Sep 2010 |
Keywords
- Autophagy
- Innate immunity
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology