Autophagy and innate immunity: Triggering, targeting and tuning

Rhea Sumpter, Beth Levine

Research output: Contribution to journalReview article

85 Scopus citations

Abstract

Autophagy is a conserved catabolic stress response pathway that is increasingly recognized as an important component of both innate and acquired immunity to pathogens. The activation of autophagy during infection not only provides cell-autonomous protection through lysosomal degradation of invading pathogens (xenophagy), but also regulates signaling by other innate immune pathways. This review will focus on recent advances in our understanding of three major areas of the interrelationship between autophagy and innate immunity, including how autophagy is triggered during infection, how invading pathogens are targeted to autophagosomes, and how the autophagy pathway participates in " tuning" the innate immune response.

Original languageEnglish (US)
Pages (from-to)699-711
Number of pages13
JournalSeminars in Cell and Developmental Biology
Volume21
Issue number7
DOIs
StatePublished - Sep 2010

Keywords

  • Autophagy
  • Innate immunity

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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