Autophagy and intestinal homeostasis

Khushbu K. Patel, Thaddeus S. Stappenbeck

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations

Abstract

Nutrient absorption is the basic function that drives mammalian intestinal biology. To facilitate nutrient uptake, the host's epithelial barrier is composed of a single layer of cells. This constraint is problematic, as a design of this type can be easily disrupted. The solution during the course of evolution was to add numerous host defense mechanisms that can help prevent local and systemic infection. These mechanisms include specialized epithelial cells that produce a physiochemical barrier overlying the cellular barrier, robust and organized adaptive and innate immune cells, and the ability to mount an inflammatory response that is commensurate with a specific threat level. The autophagy pathway is a critical cellular process that strongly influences all these functions. Therefore, a fundamental understanding of the components of this pathway and their influence on inflammation, immunity, and barrier function will facilitate our understanding of homeostasis in the gastrointestinal tract.

Original languageEnglish (US)
Pages (from-to)241-262
Number of pages22
JournalAnnual review of physiology
Volume75
DOIs
StatePublished - Feb 10 2013

Keywords

  • Crohn's disease
  • Immunity
  • Inflammation
  • Inflammatory bowel disease
  • Intestinal epithelium
  • Paneth cell
  • Xenophagy

ASJC Scopus subject areas

  • Physiology

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