Autophagy and longevity: Lessons from C. elegans

Kailiang Jia, Beth Levine

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Scopus citations

Abstract

Aging is a process in which individuals undergo an exponential decline in vitality, leading to death. In the last two decades, the study of the molecular regulation of aging in model organisms, particularly in C. elegans, has greatly expanded our knowledge of aging. Multiple longevity pathways, such as insulin-like growth factor signaling, TOR signaling, dietary restriction and mitochondrial activity, control aging in C. elegans. Recent genetic studies indicate that autophagy, an evolutionary conserved lysosomal degradation pathway, interacts with various longevity signals in the regulation of C. elegans life span. Here, we review the current progress in understanding the role of autophagy in the regulation of C. elegans life span.

Original languageEnglish (US)
Title of host publicationProtein Metabolism and Homeostasis in Aging
EditorsNektarios Tavernarakis
Pages47-60
Number of pages14
DOIs
StatePublished - Dec 1 2010

Publication series

NameAdvances in Experimental Medicine and Biology
Volume694
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Jia, K., & Levine, B. (2010). Autophagy and longevity: Lessons from C. elegans. In N. Tavernarakis (Ed.), Protein Metabolism and Homeostasis in Aging (pp. 47-60). (Advances in Experimental Medicine and Biology; Vol. 694). https://doi.org/10.1007/978-1-4419-7002-2_5