Autophagy and neurodegeneration.

Congcong He, Daniel J. Klionsky

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

Autophagy mediates the bulk degradation of cytosolic proteins and organelles. Recent studies using neuron-specific knockout mouse models demonstrate that autophagy deficiency leads to protein aggregation and neurodegeneration, even in the absence of disease-related aggregate-prone proteins.

Original languageEnglish (US)
Pages (from-to)211-213
Number of pages3
JournalACS chemical biology
Volume1
Issue number4
DOIs
StatePublished - May 23 2006

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

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