Autophagy and neurodegeneration.

Congcong He, Daniel J. Klionsky

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Autophagy mediates the bulk degradation of cytosolic proteins and organelles. Recent studies using neuron-specific knockout mouse models demonstrate that autophagy deficiency leads to protein aggregation and neurodegeneration, even in the absence of disease-related aggregate-prone proteins.

Original languageEnglish (US)
Pages (from-to)211-213
Number of pages3
JournalACS Chemical Biology
Volume1
Issue number4
DOIs
StatePublished - May 23 2006

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Autophagy
Knockout Mice
Organelles
Proteolysis
Neurons
Proteins
Agglomeration
Degradation
Protein Aggregates

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Autophagy and neurodegeneration. / He, Congcong; Klionsky, Daniel J.

In: ACS Chemical Biology, Vol. 1, No. 4, 23.05.2006, p. 211-213.

Research output: Contribution to journalArticle

He, C & Klionsky, DJ 2006, 'Autophagy and neurodegeneration.', ACS Chemical Biology, vol. 1, no. 4, pp. 211-213. https://doi.org/10.1021/cb600182h
He, Congcong ; Klionsky, Daniel J. / Autophagy and neurodegeneration. In: ACS Chemical Biology. 2006 ; Vol. 1, No. 4. pp. 211-213.
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