Autophagy and the Integrated Stress Response

Guido Kroemer, Guillermo Mariño, Beth Levine

Research output: Contribution to journalArticle

1730 Citations (Scopus)

Abstract

Autophagy is a tightly regulated pathway involving the lysosomal degradation of cytoplasmic organelles or cytosolic components. This pathway can be stimulated by multiple forms of cellular stress, including nutrient or growth factor deprivation, hypoxia, reactive oxygen species, DNA damage, protein aggregates, damaged organelles, or intracellular pathogens. Both specific, stimulus-dependent and more general, stimulus-independent signaling pathways are activated to coordinate different phases of autophagy. Autophagy can be integrated with other cellular stress responses through parallel stimulation of autophagy and other stress responses by specific stress stimuli, through dual regulation of autophagy and other stress responses by multifunctional stress signaling molecules, and/or through mutual control of autophagy and other stress responses. Thus, autophagy is a cell biological process that is a central component of the integrated stress response.

Original languageEnglish (US)
Pages (from-to)280-293
Number of pages14
JournalMolecular Cell
Volume40
Issue number2
DOIs
StatePublished - Oct 2010

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Autophagy
Organelles
Biological Phenomena
DNA Damage
Reactive Oxygen Species
Intercellular Signaling Peptides and Proteins
Food

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Autophagy and the Integrated Stress Response. / Kroemer, Guido; Mariño, Guillermo; Levine, Beth.

In: Molecular Cell, Vol. 40, No. 2, 10.2010, p. 280-293.

Research output: Contribution to journalArticle

Kroemer, Guido ; Mariño, Guillermo ; Levine, Beth. / Autophagy and the Integrated Stress Response. In: Molecular Cell. 2010 ; Vol. 40, No. 2. pp. 280-293.
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