Autophagy and viruses: Adversaries or allies?

Xiaonan Dong, Beth Levine

Research output: Contribution to journalReview article

106 Scopus citations

Abstract

The autophagy pathway is an essential component of host defense against viral infection, orchestrating pathogen degradation (xenophagy), innate immune signaling, and certain aspects of adaptive immunity. Single autophagy proteins or cassettes of the core autophagy machinery can also function as antiviral factors independently of the canonical autophagy pathway. Moreover, to survive and propagate within the host, viruses have evolved a variety of strategies to evade autophagic attack and manipulate the autophagy machinery for their own benefit. This review summarizes recent advances in understanding the antiviral and proviral roles of autophagy and previously unappreciated autophagy-independent functions of autophagy-related genes.

Original languageEnglish (US)
Pages (from-to)480-493
Number of pages14
JournalJournal of Innate Immunity
Volume5
Issue number5
DOIs
StatePublished - Jul 1 2013

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Keywords

  • Antiviral immunity
  • Autophagy
  • Virophagy

ASJC Scopus subject areas

  • Immunology and Allergy

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