Autophagy genes in immunity

Herbert W. Virgin, Beth Levine

Research output: Contribution to journalArticle

307 Citations (Scopus)

Abstract

In its classical form, autophagy is a pathway by which cytoplasmic constituents, including intracellular pathogens, are sequestered in a double-membrane-bound autophagosome and delivered to the lysosome for degradation. This pathway has been linked to diverse aspects of innate and adaptive immunity, including pathogen resistance, production of type I interferon, antigen presentation, tolerance and lymphocyte development, as well as the negative regulation of cytokine signaling and inflammation. Most of these links have emerged from studies in which genes encoding molecules involved in autophagy are inactivated in immune effector cells. However, it is not yet known whether all of the critical functions of such genes in immunity represent 'classical autophagy' or possible as-yet-undefined autophagolysosome-independent functions of these genes. This review summarizes phenotypes that result from the inactivation of autophagy genes in the immune system and discusses the pleiotropic functions of autophagy genes in immunity.

Original languageEnglish (US)
Pages (from-to)461-470
Number of pages10
JournalNature Immunology
Volume10
Issue number5
DOIs
StatePublished - 2009

Fingerprint

Autophagy
Immunity
Genes
Interferon Type I
Antigen Presentation
Gene Silencing
Adaptive Immunity
Lysosomes
Innate Immunity
Immune System
Lymphocytes
Cytokines
Inflammation
Phenotype
Membranes

ASJC Scopus subject areas

  • Immunology

Cite this

Autophagy genes in immunity. / Virgin, Herbert W.; Levine, Beth.

In: Nature Immunology, Vol. 10, No. 5, 2009, p. 461-470.

Research output: Contribution to journalArticle

Virgin, Herbert W. ; Levine, Beth. / Autophagy genes in immunity. In: Nature Immunology. 2009 ; Vol. 10, No. 5. pp. 461-470.
@article{e3425f76d0ca4dcebe4a84e9b722d57d,
title = "Autophagy genes in immunity",
abstract = "In its classical form, autophagy is a pathway by which cytoplasmic constituents, including intracellular pathogens, are sequestered in a double-membrane-bound autophagosome and delivered to the lysosome for degradation. This pathway has been linked to diverse aspects of innate and adaptive immunity, including pathogen resistance, production of type I interferon, antigen presentation, tolerance and lymphocyte development, as well as the negative regulation of cytokine signaling and inflammation. Most of these links have emerged from studies in which genes encoding molecules involved in autophagy are inactivated in immune effector cells. However, it is not yet known whether all of the critical functions of such genes in immunity represent 'classical autophagy' or possible as-yet-undefined autophagolysosome-independent functions of these genes. This review summarizes phenotypes that result from the inactivation of autophagy genes in the immune system and discusses the pleiotropic functions of autophagy genes in immunity.",
author = "Virgin, {Herbert W.} and Beth Levine",
year = "2009",
doi = "10.1038/ni.1726",
language = "English (US)",
volume = "10",
pages = "461--470",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - Autophagy genes in immunity

AU - Virgin, Herbert W.

AU - Levine, Beth

PY - 2009

Y1 - 2009

N2 - In its classical form, autophagy is a pathway by which cytoplasmic constituents, including intracellular pathogens, are sequestered in a double-membrane-bound autophagosome and delivered to the lysosome for degradation. This pathway has been linked to diverse aspects of innate and adaptive immunity, including pathogen resistance, production of type I interferon, antigen presentation, tolerance and lymphocyte development, as well as the negative regulation of cytokine signaling and inflammation. Most of these links have emerged from studies in which genes encoding molecules involved in autophagy are inactivated in immune effector cells. However, it is not yet known whether all of the critical functions of such genes in immunity represent 'classical autophagy' or possible as-yet-undefined autophagolysosome-independent functions of these genes. This review summarizes phenotypes that result from the inactivation of autophagy genes in the immune system and discusses the pleiotropic functions of autophagy genes in immunity.

AB - In its classical form, autophagy is a pathway by which cytoplasmic constituents, including intracellular pathogens, are sequestered in a double-membrane-bound autophagosome and delivered to the lysosome for degradation. This pathway has been linked to diverse aspects of innate and adaptive immunity, including pathogen resistance, production of type I interferon, antigen presentation, tolerance and lymphocyte development, as well as the negative regulation of cytokine signaling and inflammation. Most of these links have emerged from studies in which genes encoding molecules involved in autophagy are inactivated in immune effector cells. However, it is not yet known whether all of the critical functions of such genes in immunity represent 'classical autophagy' or possible as-yet-undefined autophagolysosome-independent functions of these genes. This review summarizes phenotypes that result from the inactivation of autophagy genes in the immune system and discusses the pleiotropic functions of autophagy genes in immunity.

UR - http://www.scopus.com/inward/record.url?scp=65249108735&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65249108735&partnerID=8YFLogxK

U2 - 10.1038/ni.1726

DO - 10.1038/ni.1726

M3 - Article

VL - 10

SP - 461

EP - 470

JO - Nature Immunology

JF - Nature Immunology

SN - 1529-2908

IS - 5

ER -