Autophagy, Immunity, and Microbial Adaptations

Vojo Deretic, Beth Levine

Research output: Contribution to journalReview article

599 Scopus citations

Abstract

Autophagy adjusts cellular biomass and function in response to diverse stimuli, including infection. Autophagy plays specific roles in shaping immune system development, fueling host innate and adaptive immune responses, and directly controlling intracellular microbes as a cell-autonomous innate defense. As an evolutionary counterpoint, intracellular pathogens have evolved to block autophagic microbicidal defense and subvert host autophagic responses for their survival or growth. The ability of eukaryotic pathogens to deploy their own autophagic machinery may also contribute to microbial pathogenesis. Thus, a complex interplay between autophagy and microbial adaptations against autophagy governs the net outcome of host-microbe encounters.

Original languageEnglish (US)
Pages (from-to)527-549
Number of pages23
JournalCell Host and Microbe
Volume5
Issue number6
DOIs
StatePublished - Jun 18 2009

Keywords

  • MICROBIO
  • MOLIMMUNO

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

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