Autophagy in cancer

Xiaoyong Zhi, Qing Zhong

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Autophagy is a catabolic degradation process in which cellular proteins and organelles are engulfed by double-membrane autophagosomes and degraded in lysosomes. Autophagy has emerged as a critical pathway in tumor development and cancer therapy, although its precise function remains a conundrum. The current consensus is that autophagy has a dual role in cancer. On the one hand, autophagy functions as a tumor suppressor mechanism by preventing the accumulation of damaged organelles and aggregated proteins. On the other hand, autophagy is a key cell survival mechanism for established tumors; therefore autophagy inhibition suppresses tumor progression. Here, we summarize recent progress on the role of autophagy in tumorigenesis and cancer therapy.

Original languageEnglish (US)
Article number18
JournalF1000Prime Reports
Volume7
DOIs
StatePublished - Feb 3 2015

ASJC Scopus subject areas

  • Medicine(all)

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