Autophagy in hypertensive heart disease

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

In response to hypertension, the heart manifests robust hypertrophic growth, which offsets load-induced elevations in wall stress. If sustained, this hypertrophic response is a major risk factor for systolic dysfunction and heart failure. Extensive research efforts have focused on the progression from hypertrophy to failure; however, precise understanding of underlying mechanisms remains elusive. Recently, autophagy, a process of cellular cannibalization, has been implicated. Autophagy is activated during ventricular hypertrophy, serving to maintain cellular homeostasis. Excessive autophagy eliminates, however, essential cellular elements and possibly provokes cell death, which together contribute to hypertension-related heart disease.

Original languageEnglish (US)
Pages (from-to)8509-8514
Number of pages6
JournalJournal of Biological Chemistry
Volume285
Issue number12
DOIs
StatePublished - Mar 19 2010

Fingerprint

Autophagy
Heart Diseases
Hypertrophy
Systolic Heart Failure
Hypertension
Cell death
Loads (forces)
Homeostasis
Cell Death
Growth
Research

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

Autophagy in hypertensive heart disease. / Wang, Zhao; Rothermel, Beverly A; Hill, Joseph A.

In: Journal of Biological Chemistry, Vol. 285, No. 12, 19.03.2010, p. 8509-8514.

Research output: Contribution to journalArticle

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