Autophagy in immunity and inflammation

Beth Levine, Noboru Mizushima, Herbert W. Virgin

Research output: Contribution to journalReview article

1808 Scopus citations

Abstract

Autophagy is an essential, homeostatic process by which cells break down their own components. Perhaps the most primordial function of this lysosomal degradation pathway is adaptation to nutrient deprivation. However, in complex multicellular organisms, the core molecular machinery of autophagy - the 'autophagy proteins' - orchestrates diverse aspects of cellular and organismal responses to other dangerous stimuli such as infection. Recent developments reveal a crucial role for the autophagy pathway and proteins in immunity and inflammation. They balance the beneficial and detrimental effects of immunity and inflammation, and thereby may protect against infectious, autoimmune and inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)323-335
Number of pages13
JournalNature
Volume469
Issue number7330
DOIs
StatePublished - Jan 20 2011

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Levine, B., Mizushima, N., & Virgin, H. W. (2011). Autophagy in immunity and inflammation. Nature, 469(7330), 323-335. https://doi.org/10.1038/nature09782