Autophagy in mammalian antiviral immunity

Anthony Orvedahl, Beth Levine

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Autophagy plays diverse roles in cellular adaptation to stress and promotes vital housekeeping functions by recycling unused or damaged organelles and proteins. As an innate immune defense pathway, autophagy also protects against infection with diverse pathogens, including viruses. Autophagy combats infections with both RNA and DNA viruses, and may function by degrading viral components, by promoting the survival of virally infected cells, and/or by activating innate and adaptive immunity. Viruses have evolved counter-mechanisms to evade host autophagy in order to promote their own survival. This chapter will highlight recent advances and unanswered questions relating to autophagy in mammalian antiviral immunity.

Original languageEnglish (US)
Pages (from-to)267-285
Number of pages19
JournalCurrent Topics in Microbiology and Immunology
Volume335
Issue number1
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology
  • Microbiology

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