TY - JOUR
T1 - Autophagy modulation as a potential therapeutic target for diverse diseases
AU - Rubinsztein, David C.
AU - Codogno, Patrice
AU - Levine, Beth
N1 - Funding Information:
D.C.R. is supported by the Wellcome Trust (Principal Fellowship), a Wellcome Trust/Medical Research Council Strategic Award on Neurodegenerative Diseases, the UK Medical Research Council and the National Institute for Health Research Biomedical Research Unit in Dementia at Addenbrooke’s Hospital, Cambridge, UK. B.L. is supported by US National Institutes of Health (NIH) grants RO1 CA109618 and U54AI057156. P.C. is supported by INSERM, Université Paris‑Sud 11, Agence Nationale pour la Recherche and Institut National du Cancer. The authors are grateful to F. Menzies and W. Hochfeld for technical assistance.
PY - 2012/9
Y1 - 2012/9
N2 - Autophagy is an essential, conserved lysosomal degradation pathway that controls the quality of the cytoplasm by eliminating protein aggregates and damaged organelles. It begins when double-membraned autophagosomes engulf portions of the cytoplasm, which is followed by fusion of these vesicles with lysosomes and degradation of the autophagic contents. In addition to its vital homeostatic role, this degradation pathway is involved in various human disorders, including metabolic conditions, neurodegenerative diseases, cancers and infectious diseases. This article provides an overview of the mechanisms and regulation of autophagy, the role of this pathway in disease and strategies for therapeutic modulation.
AB - Autophagy is an essential, conserved lysosomal degradation pathway that controls the quality of the cytoplasm by eliminating protein aggregates and damaged organelles. It begins when double-membraned autophagosomes engulf portions of the cytoplasm, which is followed by fusion of these vesicles with lysosomes and degradation of the autophagic contents. In addition to its vital homeostatic role, this degradation pathway is involved in various human disorders, including metabolic conditions, neurodegenerative diseases, cancers and infectious diseases. This article provides an overview of the mechanisms and regulation of autophagy, the role of this pathway in disease and strategies for therapeutic modulation.
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U2 - 10.1038/nrd3802
DO - 10.1038/nrd3802
M3 - Review article
C2 - 22935804
AN - SCOPUS:84866122688
SN - 1474-1776
VL - 11
SP - 709
EP - 730
JO - Nature Reviews Drug Discovery
JF - Nature Reviews Drug Discovery
IS - 9
ER -