Autophagy, NLRP3 inflammasome and auto-inflammatory/immune diseases

Zhenyu Zhong, Elsa Sanchez-Lopez, Michael Karin

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Loss of homeostasis, as a result of pathogen invasion or self imbalance, causes tissue damage and inflammation. In addition to its well-established role in promoting clearance of pathogens or cell corpses, inflammation is also key to drive tissue repair and regeneration. Conserved from flies to humans, a transient, well-balanced inflammatory response is critical for restoration of tissue homeostasis after damage. The absence of such a response can result in failure of tissue repair, leading to the development of devastating immunopathologies and degenerative diseases. Studies in the past decade collectively suggest that a malfunction of NLRP3 inflammasome, a key tissue damage sensor, is a dominant driver of various autoinflammatory and autoimmune diseases, including gout, rheumatoid arthritis, and lupus. It is therefore crucial to understand the biology and regulation of NLRP3 inflammasome and determine its affect in the context of various diseases. Of note, various studies suggest that autophagy, a cellular waste removal and rejuvenation process, serves an important role as a macrophage-intrinsic negative regulator of NLRP3 inflammasome. Here, we review recent advances in understanding how autophagy regulates NLRP3 inflammasome activity and discuss the implications of this regulation on the pathogenesis of autoinflammatory and autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)12-16
Number of pages5
JournalClinical and experimental rheumatology
Volume34
StatePublished - Jan 1 2016
Externally publishedYes

Fingerprint

Inflammasomes
Immune System Diseases
Autophagy
Autoimmune Diseases
Homeostasis
Inflammation
Rejuvenation
Gout
Cadaver
Diptera
Regeneration
Rheumatoid Arthritis
Macrophages

Keywords

  • Auto-inflammatory diseases
  • Autophagy
  • Immune diseases
  • Mitochondria
  • Mitophagy
  • mtDNA
  • mtROS
  • NLRP3 inflammasome

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Autophagy, NLRP3 inflammasome and auto-inflammatory/immune diseases. / Zhong, Zhenyu; Sanchez-Lopez, Elsa; Karin, Michael.

In: Clinical and experimental rheumatology, Vol. 34, 01.01.2016, p. 12-16.

Research output: Contribution to journalArticle

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