Autophagy Regulation of Metabolism Is Required for CD8                         +                          T Cell Anti-tumor Immunity

Lindsay DeVorkin; Nils Pavey; Gillian Carleton; Alexandra Comber; Cally Ho; Junghyun Lim; Erin McNamara; Haochu Huang; Paul Kim; Lauren G. Zacharias; Noboru Mizushima; Tatsuya Saitoh; Shizuo Akira; Wayne Beckham; Alireza Lorzadeh; Michelle Moksa; Qi Cao; Aditya Murthy; Martin Hirst; Ralph J. DeBerardinis; Julian J. Lum

doi:10.1016/j.celrep.2019.03.037

Autophagy Regulation of Metabolism Is Required for CD8 ⁺ T Cell Anti-tumor Immunity

Lindsay DeVorkin, Nils Pavey, Gillian Carleton, Alexandra Comber, Cally Ho, Junghyun Lim, Erin McNamara, Haochu Huang, Paul Kim, Lauren G. Zacharias, Noboru Mizushima, Tatsuya Saitoh, Shizuo Akira, Wayne Beckham, Alireza Lorzadeh, Michelle Moksa, Qi Cao, Aditya Murthy, Martin Hirst, Ralph J. DeBerardinisJulian J. Lum

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

DeVorkin et al. show that loss of autophagy enhances CD8 ⁺ T-cell-mediated rejection of tumors. Mechanistically, suppression of autophagy shifts T cells to a glycolytic phenotype and causes a reduction in S-adenosylmethionine. As a consequence, autophagy-deficient T cells transcriptionally reprogram immune response genes to an effector memory state.

Original language	English (US)
Pages (from-to)	502-513.e5
Journal	Cell Reports
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2019.03.037
State	Published - Apr 9 2019

Keywords

CD8 T cells
SAM
anti-tumor immunity
autophagy
glycolysis
lactate
methylation

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/j.celrep.2019.03.037

Cite this

DeVorkin, L., Pavey, N., Carleton, G., Comber, A., Ho, C., Lim, J., McNamara, E., Huang, H., Kim, P., Zacharias, L. G., Mizushima, N., Saitoh, T., Akira, S., Beckham, W., Lorzadeh, A., Moksa, M., Cao, Q., Murthy, A., Hirst, M., ... Lum, J. J. (2019). Autophagy Regulation of Metabolism Is Required for CD8 ⁺ T Cell Anti-tumor Immunity Cell Reports, 27(2), 502-513.e5. https://doi.org/10.1016/j.celrep.2019.03.037

DeVorkin, L, Pavey, N, Carleton, G, Comber, A, Ho, C, Lim, J, McNamara, E, Huang, H, Kim, P, Zacharias, LG, Mizushima, N, Saitoh, T, Akira, S, Beckham, W, Lorzadeh, A, Moksa, M, Cao, Q, Murthy, A, Hirst, M, DeBerardinis, RJ & Lum, JJ 2019, ' Autophagy Regulation of Metabolism Is Required for CD8 ⁺ T Cell Anti-tumor Immunity ', Cell Reports, vol. 27, no. 2, pp. 502-513.e5. https://doi.org/10.1016/j.celrep.2019.03.037

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title = " Autophagy Regulation of Metabolism Is Required for CD8 + T Cell Anti-tumor Immunity ",

abstract = " DeVorkin et al. show that loss of autophagy enhances CD8 + T-cell-mediated rejection of tumors. Mechanistically, suppression of autophagy shifts T cells to a glycolytic phenotype and causes a reduction in S-adenosylmethionine. As a consequence, autophagy-deficient T cells transcriptionally reprogram immune response genes to an effector memory state.",

keywords = "CD8 T cells, SAM, anti-tumor immunity, autophagy, glycolysis, lactate, methylation",

author = "Lindsay DeVorkin and Nils Pavey and Gillian Carleton and Alexandra Comber and Cally Ho and Junghyun Lim and Erin McNamara and Haochu Huang and Paul Kim and Zacharias, {Lauren G.} and Noboru Mizushima and Tatsuya Saitoh and Shizuo Akira and Wayne Beckham and Alireza Lorzadeh and Michelle Moksa and Qi Cao and Aditya Murthy and Martin Hirst and DeBerardinis, {Ralph J.} and Lum, {Julian J.}",

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AU - DeVorkin, Lindsay

AU - Pavey, Nils

AU - Carleton, Gillian

AU - Comber, Alexandra

AU - Ho, Cally

AU - Lim, Junghyun

AU - McNamara, Erin

AU - Huang, Haochu

AU - Kim, Paul

AU - Zacharias, Lauren G.

AU - Mizushima, Noboru

AU - Saitoh, Tatsuya

AU - Akira, Shizuo

AU - Beckham, Wayne

AU - Lorzadeh, Alireza

AU - Moksa, Michelle

AU - Cao, Qi

AU - Murthy, Aditya

AU - Hirst, Martin

AU - DeBerardinis, Ralph J.

AU - Lum, Julian J.

PY - 2019/4/9

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KW - CD8 T cells

KW - SAM

KW - anti-tumor immunity

KW - autophagy

KW - glycolysis

KW - lactate

KW - methylation

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