Autophagy Regulation of Metabolism Is Required for CD8 + T Cell Anti-tumor Immunity

Lindsay DeVorkin, Nils Pavey, Gillian Carleton, Alexandra Comber, Cally Ho, Junghyun Lim, Erin McNamara, Haochu Huang, Paul Kim, Lauren G. Zacharias, Noboru Mizushima, Tatsuya Saitoh, Shizuo Akira, Wayne Beckham, Alireza Lorzadeh, Michelle Moksa, Qi Cao, Aditya Murthy, Martin Hirst, Ralph J. DeBerardinisJulian J. Lum

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

DeVorkin et al. show that loss of autophagy enhances CD8 + T-cell-mediated rejection of tumors. Mechanistically, suppression of autophagy shifts T cells to a glycolytic phenotype and causes a reduction in S-adenosylmethionine. As a consequence, autophagy-deficient T cells transcriptionally reprogram immune response genes to an effector memory state.

Original languageEnglish (US)
Pages (from-to)502-513.e5
JournalCell Reports
Volume27
Issue number2
DOIs
StatePublished - Apr 9 2019

Keywords

  • CD8 T cells
  • SAM
  • anti-tumor immunity
  • autophagy
  • glycolysis
  • lactate
  • methylation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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