Autoradiographic localization of [125I]-endothelin-1 binding sites in rat brain

Chizuko Koseki, Masashi Imai, Yukio Hirata, Masashi Yanagisawa, Tomoh Masaki

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43 Scopus citations


Autoradiograms of [125I]-endothelin (ET) binding in the rat brain demonstrated that the receptors for endothelin are localized mainly in the brainstem, basal ganglia, and cerebellum. Among the many other nuclei in these regions, there also appeared nuclei which are considered to play important roles in the central nervous regulation of the cardiovascular system: they include the nuclei of the anteroventral third ventricle area, the supraoptic nucleus, and the subfornical organ, for example. From these findings, we suggest that ET-1 or its analogous peptide(s) may act as a neuropeptide regulating central nervous functions, including cardiovascular functions.

Original languageEnglish (US)
Pages (from-to)581-585
Number of pages5
JournalNeuroscience Research
Issue number6
StatePublished - Aug 1989


  • Cardiovascular regulatory nuclei
  • Central nervous system
  • Endothelin
  • Receptor
  • Vasoconstrictor

ASJC Scopus subject areas

  • Neuroscience(all)


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