TY - JOUR
T1 - Autoradiographic localization of [125I]-endothelin-1 binding sites in rat brain
AU - Koseki, Chizuko
AU - Imai, Masashi
AU - Hirata, Yukio
AU - Yanagisawa, Masashi
AU - Masaki, Tomoh
PY - 1989/8
Y1 - 1989/8
N2 - Autoradiograms of [125I]-endothelin (ET) binding in the rat brain demonstrated that the receptors for endothelin are localized mainly in the brainstem, basal ganglia, and cerebellum. Among the many other nuclei in these regions, there also appeared nuclei which are considered to play important roles in the central nervous regulation of the cardiovascular system: they include the nuclei of the anteroventral third ventricle area, the supraoptic nucleus, and the subfornical organ, for example. From these findings, we suggest that ET-1 or its analogous peptide(s) may act as a neuropeptide regulating central nervous functions, including cardiovascular functions.
AB - Autoradiograms of [125I]-endothelin (ET) binding in the rat brain demonstrated that the receptors for endothelin are localized mainly in the brainstem, basal ganglia, and cerebellum. Among the many other nuclei in these regions, there also appeared nuclei which are considered to play important roles in the central nervous regulation of the cardiovascular system: they include the nuclei of the anteroventral third ventricle area, the supraoptic nucleus, and the subfornical organ, for example. From these findings, we suggest that ET-1 or its analogous peptide(s) may act as a neuropeptide regulating central nervous functions, including cardiovascular functions.
KW - Cardiovascular regulatory nuclei
KW - Central nervous system
KW - Endothelin
KW - Receptor
KW - Vasoconstrictor
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U2 - 10.1016/0168-0102(89)90047-3
DO - 10.1016/0168-0102(89)90047-3
M3 - Article
C2 - 2677844
AN - SCOPUS:0024472694
SN - 0168-0102
VL - 6
SP - 581
EP - 585
JO - Neuroscience Research
JF - Neuroscience Research
IS - 6
ER -