Abstract
We investigated endothelin-1 (ET-1) receptor expression on normal human keratinocytes (HK). We show that HK express the ETB receptor isoform and respond to ET-1 with a 2.7-fold increase in intracellular free calcium. HK did not respond to ET-1 with increased proliferation; however, 30 nM ET-1 caused a 51.7% decrease in ET-1 accumulation in HK-conditioned medium. We propose that HK ET-1 receptors function in autocrine regulation of ET-1 secretion.
Original language | English (US) |
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Pages (from-to) | 454-458 |
Number of pages | 5 |
Journal | BBA - Molecular Cell Research |
Volume | 1224 |
Issue number | 3 |
DOIs | |
State | Published - Dec 30 1994 |
Keywords
- (Human)
- Calcium
- Endothelin-1
- Keratinocyte
- Receptor
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology