Autoregulation of renal and splanchnic blood flow following infra-renal aortic clamping is mediated by nitric oxide and vasodilator prostanoids

S. I. Myers, R. H. Turnage, R. Hernandez, A. Castenada, R. J. Valentine

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective. This study examines the hypothesis that nitric oxide and vasodilator prostanoids contribute to the autoregulation of renal artery and superior mesenteric artery (SMA) blood flow following infra-renal aortic clamping. Experimental design. Renal and SMA artery blood flow were measured in anesthetized rats. The rats received bolus injection of saline carrier, L-NAME (25 mg/kg) or indomethacin (15 mg/kg) prior to sham or infra-renal aortic occlusion. In vivo blood flow was measured 1, 30 and 60 minutes during aortic occlusion and 1, 30, and 60 minutes following release of the aortic cross clamp. Results. Aortic occlusion transiently increased SMA blood now but did not alter renal artery blood flow. Aortic clamp release resulted in a 40% decrease in both SMA and renal artery blood flow, L-NAME or indomethacin pretreatment decreased both SMA and renal artery blood flow at 60 minutes following infra-renal aortic occlusion. Indomethacin decreased SMA blood now at 1 minute following unclamping of the aorta and L-NAME decreased SMA blood flow at 30 and 60 minutes following aortic clamp release. Both L-NAME and indomethacin markedly decreased renal artery blood flow at all time periods following aortic clamp release. Conclusions. These data suggest that renal and splanchnic vascular beds utilize endogenous vasodilator eicosanoids and nitric oxide to maintain blood now during cross clamping and unclamping of the infra-renal aorta.

Original languageEnglish (US)
Pages (from-to)97-103
Number of pages7
JournalJournal of Cardiovascular Surgery
Volume37
Issue number2
StatePublished - Apr 1996

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Superior Mesenteric Artery
Viscera
Renal Circulation
Vasodilator Agents
Constriction
Prostaglandins
Nitric Oxide
Homeostasis
Renal Artery
Kidney
NG-Nitroarginine Methyl Ester
Indomethacin
Aorta
Eicosanoids
Blood Vessels
Research Design
Arteries
Injections

Keywords

  • Free radicals, oxygen-derived
  • Nitric oxide
  • Renal blood flow

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Autoregulation of renal and splanchnic blood flow following infra-renal aortic clamping is mediated by nitric oxide and vasodilator prostanoids. / Myers, S. I.; Turnage, R. H.; Hernandez, R.; Castenada, A.; Valentine, R. J.

In: Journal of Cardiovascular Surgery, Vol. 37, No. 2, 04.1996, p. 97-103.

Research output: Contribution to journalArticle

Myers, S. I. ; Turnage, R. H. ; Hernandez, R. ; Castenada, A. ; Valentine, R. J. / Autoregulation of renal and splanchnic blood flow following infra-renal aortic clamping is mediated by nitric oxide and vasodilator prostanoids. In: Journal of Cardiovascular Surgery. 1996 ; Vol. 37, No. 2. pp. 97-103.
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N2 - Objective. This study examines the hypothesis that nitric oxide and vasodilator prostanoids contribute to the autoregulation of renal artery and superior mesenteric artery (SMA) blood flow following infra-renal aortic clamping. Experimental design. Renal and SMA artery blood flow were measured in anesthetized rats. The rats received bolus injection of saline carrier, L-NAME (25 mg/kg) or indomethacin (15 mg/kg) prior to sham or infra-renal aortic occlusion. In vivo blood flow was measured 1, 30 and 60 minutes during aortic occlusion and 1, 30, and 60 minutes following release of the aortic cross clamp. Results. Aortic occlusion transiently increased SMA blood now but did not alter renal artery blood flow. Aortic clamp release resulted in a 40% decrease in both SMA and renal artery blood flow, L-NAME or indomethacin pretreatment decreased both SMA and renal artery blood flow at 60 minutes following infra-renal aortic occlusion. Indomethacin decreased SMA blood now at 1 minute following unclamping of the aorta and L-NAME decreased SMA blood flow at 30 and 60 minutes following aortic clamp release. Both L-NAME and indomethacin markedly decreased renal artery blood flow at all time periods following aortic clamp release. Conclusions. These data suggest that renal and splanchnic vascular beds utilize endogenous vasodilator eicosanoids and nitric oxide to maintain blood now during cross clamping and unclamping of the infra-renal aorta.

AB - Objective. This study examines the hypothesis that nitric oxide and vasodilator prostanoids contribute to the autoregulation of renal artery and superior mesenteric artery (SMA) blood flow following infra-renal aortic clamping. Experimental design. Renal and SMA artery blood flow were measured in anesthetized rats. The rats received bolus injection of saline carrier, L-NAME (25 mg/kg) or indomethacin (15 mg/kg) prior to sham or infra-renal aortic occlusion. In vivo blood flow was measured 1, 30 and 60 minutes during aortic occlusion and 1, 30, and 60 minutes following release of the aortic cross clamp. Results. Aortic occlusion transiently increased SMA blood now but did not alter renal artery blood flow. Aortic clamp release resulted in a 40% decrease in both SMA and renal artery blood flow, L-NAME or indomethacin pretreatment decreased both SMA and renal artery blood flow at 60 minutes following infra-renal aortic occlusion. Indomethacin decreased SMA blood now at 1 minute following unclamping of the aorta and L-NAME decreased SMA blood flow at 30 and 60 minutes following aortic clamp release. Both L-NAME and indomethacin markedly decreased renal artery blood flow at all time periods following aortic clamp release. Conclusions. These data suggest that renal and splanchnic vascular beds utilize endogenous vasodilator eicosanoids and nitric oxide to maintain blood now during cross clamping and unclamping of the infra-renal aorta.

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