Autosis and autophagic cell death: The dark side of autophagy

Y. Liu, Beth Levine

Research output: Contribution to journalReview article

330 Scopus citations

Abstract

It is controversial whether cells truly die via autophagy or whether - in dying cells - autophagy is merely an innocent bystander or a well-intentioned 'Good Samaritan' trying to prevent inevitable cellular demise. However, there is increasing evidence that the genetic machinery of autophagy may be essential for cell death in certain settings. We recently identified a novel form of autophagy gene-dependent cell death, termed autosis, which is mediated by the Na+,K+-ATPase pump and has unique morphological features. High levels of cellular autophagy, as occurs with treatment with autophagy-inducing peptides, starvation, or in vivo during certain types of ischemia, can trigger autosis. These findings provide insights into the mechanisms and strategies for prevention of cell death during extreme stress conditions.

Original languageEnglish (US)
Pages (from-to)367-376
Number of pages10
JournalCell Death and Differentiation
Volume22
Issue number3
DOIs
StatePublished - Sep 26 2015

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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