Autosomal dominant neurological disorder

R. O. Brady, R. N. Rosenberg

Research output: Contribution to journalArticle

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Abstract

Genetic disease in the United States poses an immense problem, with 6% of the population having a genetically related disease, 30% of hospitalized children having a genetically based disorder, and 80% of mental retardation directly due to a genetic entity. In order to develop a general scientific strategy and possible molecular models of dominantly inherited diseases, a symposium was held in Bethesda, MD, on April 6 and 7, 1978. Fifty invited speakers and informal participants considered emerging and established dominantly inherited entities, examined as model approaches disorders in which the molecular pathology is reasonably well understood, considered in detail biochemical implications of genetic patterns, and discussed specific molecular mechanisms that might explain the expression of dominant diseases.

Original languageEnglish (US)
Pages (from-to)548-553
Number of pages6
JournalAnnals of Neurology
Volume4
Issue number6
StatePublished - Dec 1 1978

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ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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